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	Provedor de dados BJM (1) Autor Chang-Jian,Sun (1) Dong-Ya,Meng (1) Jing-Bo,Yu (1) Jun,Ma (1) Wen-Cheng,Xue (1) Palavra-chave Drug resistance (1) Mutation (1) Mycoplasma hominis (1) Quinolones (1) Tipo do documento Info:eu-repo/semantics/article (1) Ano 2014 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Molecular mechanism of fluoroquinolones resistance in Mycoplasma hominis clinical isolates BJM Dong-Ya,Meng; Chang-Jian,Sun; Jing-Bo,Yu; Jun,Ma; Wen-Cheng,Xue. To evaluate the molecular mechanism of fluoroquinolones resistance in Mycoplasma hominis (MH) clinical strains isolated from urogenital specimens. 15 MH clinical isolates with different phenotypes of resistance to fluoroquinolones antibiotics were screened for mutations in the quinolone resistance-determining regions (QRDRs) of DNA gyrase (gyrA and gyrB) and topoisomerase IV (parC and parE) in comparison with the reference strain PG21, which is susceptible to fluoroquinolones antibiotics. 15 MH isolates with three kinds of quinolone resistance phenotypes were obtained. Thirteen out of these quinolone-resistant isolates were found to carry nucleotide substitutions in either gyrA or parC. There were no alterations in gyrB and no mutations were found in the... Tipo: Info:eu-repo/semantics/article Palavras-chave: Mycoplasma hominis; Quinolones; Drug resistance; Mutation. Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822014000100034 Registros recuperados: 1 Primeira ... 1 ... Última

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