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	Provedor de dados 56 (2) Autor Joelsons,G. (2) Manfro,R.C. (2) Domenico,T. (1) Domenico,T.D. (1) Gonçalves,L.F. (1) Montenegro,R.M. (1) Mais... Palavra-chave Gene expression (2) Acute rejection (1) Biomarker (1) Diagnosis (1) Graft dysfunction (1) Kidney transplantation (1) MRNA (1) MicroRNA (1) Renal transplantation (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2018 (1) 2017 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Upregulation of microRNA 142-3p in the peripheral blood and urinary cells of kidney transplant recipients with post-transplant graft dysfunction 56 Domenico,T.D.; Joelsons,G.; Montenegro,R.M.; Manfro,R.C.. We analyzed microRNA (miR)-142-3p expression in leucocytes of the peripheral blood and urinary sediment cell samples obtained from kidney transplant recipients who developed graft dysfunction. Forty-one kidney transplant recipients with kidney graft dysfunction and 8 stable patients were included in the study. The groups were divided according to histological analysis into acute rejection group (n=23), acute tubular necrosis group (n=18) and stable patients group used as a control for gene expression (n=8). Percutaneous biopsies were performed and peripheral blood samples and urine samples were obtained. miR-142-3p was analyzed by real-time polymerase chain reaction. The group of patients with acute tubular necrosis presented significantly higher... Tipo: Info:eu-repo/semantics/article Palavras-chave: MicroRNA; Graft dysfunction; Renal transplantation; Gene expression; Biomarker. Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017000400605 Non-invasive messenger RNA transcriptional evaluation in human kidney allograft dysfunction 56 Joelsons,G.; Domenico,T.; Gonçalves,L.F.; Manfro,R.C.. The aim of the present study was to evaluate messenger RNA expression in kidney allograft recipients. Forty-four kidney transplant recipients were evaluated up to three months after grafting. After transplantation, peripheral blood samples were drawn sequentially for real-time polymerase chain reaction analyses of perforin and TIM-3 genes. Biopsies were obtained to evaluate acute graft dysfunction and interpreted according to the Banff classification. Eight patients presented episodes of acute rejection. Recipients with rejection had significantly higher levels of TIM-3 mRNA transcripts compared to those without rejection (median gene expression 191.2 and 36.9 mRNA relative units, respectively; P<0.0001). Also, perforin gene expression was higher in... Tipo: Info:eu-repo/semantics/article Palavras-chave: Kidney transplantation; Acute rejection; Gene expression; Diagnosis; MRNA. Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000700608 Registros recuperados: 2 Primeira ... 1 ... Última

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