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| Registros recuperados: 11 | |
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| Sader,Helio S.; Jones,Ronald N.; Ballow,Charles H.; Biedenbach,Douglas J.; Cereda,Rosangela F.. |
| Gram-positive cocci are important causes of both nosocomial and community-acquired infections, and antimicrobial resistance among these pathogens has become an important problem worldwide. Since resistance among these organisms can vary substantially by geographic location, we conducted a multicenter surveillance study with isolates from five Latin American countries (15 medical centers). Quinupristin/dalfopristin (formerly RP-59500) is a novel streptogramin combination with focused activity against Gram-positive cocci, many exhibiting emerging resistance. The in vitro activity of quinupristin/dalfopristin and 12 other antimicrobial agents were evaluated against 1,948 strains including Staphylococcus aureus (747 strains), coagulase-negative staphylococci... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Quinupristin/dalfopristin; Gram-positive cocci; SMART; Antimicrobial surveillance. |
| Ano: 2001 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702001000100004 |
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| Flamm,Robert K.; Sader,Helio S.; Jones,Ronald N.. |
| A total of 2484 target bacterial pathogens were collected (one per patient episode) from patients in 16 Latin American medical centers located in seven nations during 2011. Isolate identity was confirmed at a coordinating laboratory and susceptibility testing was performed for ceftaroline and comparator agents according to reference broth microdilution methods. A total of 30.0% of isolates were from respiratory tract, 29.4% from skin and skin structure, 21.4% from blood stream, 7.9% from urinary tract and 11.3% from other sites. Ceftaroline was active againstStaphylococcus aureus (42.8% MRSA) with 83.6% of the isolates at <1mg/L and all isolates at <2mg/L (MIC5090, 0.25/2mg/L). National MRSA rates ranged from a low of 28.8% in Colombia to a high of... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Ceftaroline; Latin America; AWARE. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000200187 |
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| Flamm,Robert K.; Sader,Helio S.; Jones,Ronald N.. |
| Ceftaroline, the active metabolite of the prodrug ceftaroline fosamil, is a cephalosporin with in vitro bactericidal activity against Gram-positive organisms, including methicillinsusceptible and -resistant Staphylococcus aureus, β-haemolytic and viridans group streptococci, and Streptococcus pneumoniae, as well as common Gram-negative organisms. In this study a total of 986 isolates collected in 2010 from patients in 15 medical centers in five Latin American countries from the Assessing Worldwide Antimicrobial Resistance Evaluation Program were identified as community-acquired respiratory tract or skin and soft tissue infection pathogens. Ceftaroline was the most potent agent tested against S. pneumoniae with a MIC90 value (0.12 µg/mL) that was eight-fold... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Ceftaroline; AWARE; S. aureus; S. pneumoniae. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000500009 |
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| Cereda,Rosangela F.; Sader,Helio S.; Jones,Ronald N.; Sejas,Lilian; Machado,Antônia M.; Zanatta,Yara P.; Rego,Sinaida T. M. S.; Medeiros,Eduardo A. S.. |
| We report for the first time in Brazil, a patient from whom an Enterococcus faecalis VanA phenotype was isolated. Glycopeptide resistance is not commonly observed in Enterococcus faecalis, so this finding is of great concern since this species is responsible for 90% of enterococcal infections in Brazil. The isolate was recovered from a surveillance rectal swab culture from a patient with acute lymphocytic leukemia (ALL). Identification to the species level was performed by conventional biochemical tests and Vitek GPI cards. Antimicrobial susceptibility testing was evaluated by use of broth microdilution and Etest (AB BIODISK, Solna, Sweden) methods. The isolate was identified as E. faecalis and was considered resistant to both vancomycin (MIC, > 256... |
| Tipo: Info:eu-repo/semantics/report |
Palavras-chave: Enterococcus faecalis; Glycopeptide resistance; VanA; Initial case report; Transplant. |
| Ano: 2001 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702001000100007 |
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| Sader,Helio S.; Gales,Ana C.; Pfaller,Michael A.; Mendes,Rodrigo E.; Zoccoli,Cássia; Barth,Afonso; Jones,Ronald N.. |
| BACKGROUND: Pathogen frequency and resistance patterns may vary significantly from country to country and also in different hospitals within a country. Thus, regional surveillance programs are essential to guide empirical therapy and infection control measures. METHODS: Rank order of occurrence and antimicrobial susceptibility of pathogenic species causing bloodstream infections (BSI), lower respiratory tract infections (LRTI), wound or skin and soft tissue infections (WSSTI), and urinary tract infections (UTI) in hospitalized patients were determined by collecting consecutive isolates over a specified period of time, as part of the SENTRY Antimicrobial Resistance Surveillance Program (SENTRY). All isolates were tested by reference broth microdilution.... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: SENTRY; Antimicrobial resistance; Nosocomial infection; Surveillance program. |
| Ano: 2001 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702001000400006 |
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| Jones,Ronald N.; Guzman-Blanco,Manuel; Gales,Ana C.; Gallegos,Belisario; Castro,Aura Lucia Leal; Martino,Marines Dalla Valle; Vega,Silvio; Zurita,Jeannete; Cepparulo,Mario; Castanheira,Mariana. |
| OBJECTIVE: To establish a resistance (R) surveillance program monitoring antimicrobial susceptibility patterns in Latin America (LATAM; Argentina [ARG], Brazil [BRA], Chile, Colombia [CBA], Costa Rica, Ecuador [ECU], Guatemala [GUA], Mexico [MEX], Panama [PAN], Peru, and Venezuela [VEN]). METHODS: In 2011, 4979 organisms were collected from 11 nations (20 laboratories) for susceptibility testing in a central laboratory design. Antimicrobials were tested by CLSI methods and results interpreted by CLSI and EUCAST breakpoints. Most common Gram-positive (Staphylococcus aureus [SA, 921], other staphylococci [CoNS; 299], enterococci [218], Streptococcus pneumoniae [SPN; 182], β-haemolytic streptococci [115]) and Gram-negative (E. coli [EC; 644], Klebsiella spp.... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Latin America; Surveillance; Resistance; ESBL; Β-Lactamases. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000600009 |
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| Gales,Ana C.; Jones,Ronald N.; Andrade,Soraya S.; Pereira,Andrea S.; Sader,Hélio S.. |
| The in vitro activity of tigecycline (former GAR-936), a new semisynthetic tetracycline, was evaluated in comparison with tetracycline and other antimicrobial agents. MATERIAL AND METHODS: A total of 1,326 contemporary clinical isolates collected from the Latin American region were collected in 2000-2002 period and tested with microdilution broth according to the CLSI guidelines. The bacterial pathogens evaluated included Staphylococcus aureus (505), Streptococcus pneumoniae (269), coagulase-negative staphylococci (CoNS; 227), Haemophilus influenzae (129), Enterococcus spp. (80), Moraxella catarrhalis (54), beta-haemolytic streptococci (28), viridans group streptococci (26), and Neisseria meningitidis (8) RESULTS:Tigecycline demonstrated excellent activity... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Antimicrobial susceptibility; Tigecycline; Latin America and SENTRY. |
| Ano: 2005 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000500001 |
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| Registros recuperados: 11 | |
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