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	Provedor de dados Nature Precedings (1) Autor Andrew L. Varnell (1) Donald C. Cooper (1) Juan A. Varela (1) Jungang Wang (1) Palavra-chave Neuroscience (1) Tipo do documento Manuscript (1) Ano 2011 (1) País United Kingdom (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Control over stress induces plasticity of individual prefrontal cortical neurons: A conductance-based neural simulation Nature Precedings Juan A. Varela; Jungang Wang; Andrew L. Varnell; Donald C. Cooper. Behavioral control over stressful stimuli induces resilience to future conditions when control is lacking. The medial prefrontal cortex(mPFC) is a critically important brain region required for plasticity of stress resilience. We found that control over stress induces plasticity of the intrinsic voltage-gated conductances of pyramidal neurons in the PFC. To gain insight into the underlying biophysical mechanisms of this plasticity we used the conductance- based neural simulation software tool, NEURON, to model the increase in membrane excitability associated with resilience to stress. A ball and stick multicompartment conductance-based model was used to realistically fit passive and active data traces from prototypical pyramidal neurons in neurons in rats... Tipo: Manuscript Palavras-chave: Neuroscience. Ano: 2011 URL: http://precedings.nature.com/documents/6267/version/1 Registros recuperados: 1 Primeira ... 1 ... Última

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