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	Provedor de dados 17 (1) Autor Amineni Umamaheswari (1) Dibyabhaba Pradhan (1) Karuna J. Jaya Sai (1) Palavra-chave Bioinformatics (1) Cancer (1) Tipo do documento Poster (1) Ano 2010 (1) País United Kingdom (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Computerized Protein Modeling and Molecular Docking Analysis of Human Proto Oncogene Tyrosine Protein Kinase YES for Discovery of Novel Lead Molecules 17 Karuna J. Jaya Sai; Dibyabhaba Pradhan; Amineni Umamaheswari. Human proto-oncogene tyrosine-protein kinase YES (YES) is a non receptor kinase belongs to Src family. This gene lies in close proximity to thymidylate synthase gene on chromosome 18, and a corresponding pseudogene has been found on chromosome 22. In hepatocellular carcinoma and colorectal carcinoma elevated human YES activity was observed. Inhibitors of human YES reported till date are in clinical trials and associated with several side effects. The present study was mainly aimed in homology modeling of human YES and discovery of novel lead molecules that inhibit YES kinase more efficiently with fewer side effects. Virtual screening and docking techniques were applied to identify novel lead molecule of YES kinase. As there was no reported human YES... Tipo: Poster Palavras-chave: Cancer; Bioinformatics. Ano: 2010 URL: http://precedings.nature.com/documents/4902/version/1 Registros recuperados: 1 Primeira ... 1 ... Última

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