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| Fujitani,Kazuko; Otomo,Asako; Nagayama,Yuto; Tachibana,Taro; Kato,Rika; Kawashima,Yusuke; Kodera,Yoshio; Kato,Tomoko; Takada,Shuji; Tamura,Kei; Takamatsu,Nobuhiko; Ito,Michihiko. |
| Abstract The transcription factor DMRT1 (doublesex and mab-3 related transcription factor) has two distinct functions, somatic-cell masculinization and germ-cell development in some vertebrate species, including mouse and the African clawed frog Xenopus laevis. However, its transcriptional regulation remains unclear. We tried to identify DMRT1-interacting proteins from X. laevis testes by immunoprecipitation with an anti-DMRT1 antibody and MS/MS analysis, and selected three proteins, including PACT/PRKRA (Interferon-inducible double-stranded RNA dependent protein kinase activator A) derived from testes. Next, we examined the effects of PACT/PRKRA and/or p53 on the transcriptional activity of DMRT1. In transfected 293T cells, PACT/PRKRA and p53... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: P53; DMRT1; Germline stem cell; Testis; Xenopus. |
| Ano: 2020 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572020000400702 |
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