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	Provedor de dados Nature Precedings (1) Autor Gauri Tendulkar (1) Ketaki Ghate (1) Milind Watve (1) Palavra-chave Molecular Cell Biology (1) Tipo do documento Poster (1) Ano 2010 (1) País United Kingdom (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última A probabilistic model of plasmid replication regulation by a combination of handcuffing, iteron number and dimerization of RepA protein. Nature Precedings Milind Watve; Gauri Tendulkar; Ketaki Ghate. Plasmids are small circular DNA molecules in bacteria which replicate sharing the replication machinery with the bacterial chromosome. Since plasmids are much smaller than the chromosome, unless their replication is tightly regulated, their copy numbers can escalate quickly. A number of mechanisms of plasmid replication regulation are known in P1 plasmid of E. coli. Mechanisms such as autorepression of the replication initiator protein (RepA) and its dimerization are unable to explain copy number regulation by themselves. The number of RepA binding sites (iterons) is inversely related to copy numbers. Handcuffing of plasmids by RepA dimer is believed to be the main mechanism of arresting replication. We show here with a probabilistic model that for the... Tipo: Poster Palavras-chave: Molecular Cell Biology. Ano: 2010 URL: http://precedings.nature.com/documents/5421/version/1 Registros recuperados: 1 Primeira ... 1 ... Última

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