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	Provedor de dados Nature Precedings (3) Autor Jean-Claude Bradley (3) Khalid Mirza (3) Alisha Merchant (1) Andrew Lang (1) Antony Williams (1) David Bulger (1) Emily Messner (1) Jiri Gut (1) Kevin Owens (1) Marshall Moritz (1) Mitesh Shah (1) Philip Rosenthal (1) Rajarshi Guha (1) Rikesh Parikh (1) Shannon Oseback (1) Tim Bohinski (1) Tom Osborne (1) Mais... Palavra-chave Chemistry (3) Bioinformatics (1) Pharmacology (1) Tipo do documento Manuscript (2) Presentation (1) Ano 2010 (1) 2008 (2) País United Kingdom (3)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 3 Primeira ... 1 ... Última Open Notebook Science - Falcipain-2 Preliminary Results Nature Precedings Jean-Claude Bradley; Philip Rosenthal; Rajarshi Guha; Khalid Mirza; Jiri Gut. This talk was presented by Jean-Claude Bradley at the American Chemical Society meeting in Philadelphia on August 20, 2008. An introduction to Open Notebook Science is presented followed by an illustration of how ONS can be used in drug discovery. New data relating to the anti-malarial activity of Ugi products on 2 falcipain-2 docking sites is detailed. The docking calculations were provided by Rajarshi Guha and the enzyme and in vitro assays on Plasmodium falciparum were provided by Phil Rosenthal and Jiri Gut. Most of the syntheses were carried out by Khalid Mirza in the Bradley group.

Screencast available at:... Tipo: Presentation Palavras-chave: Chemistry; Bioinformatics. Ano: 2008 URL: http://precedings.nature.com/documents/2216/version/1 Optimization of the Ugi reaction using parallel synthesis and automated liquid handling Nature Precedings Jean-Claude Bradley; Khalid Mirza; Kevin Owens; Tom Osborne; Antony Williams. The Ugi reaction has proved to be a convenient way to quickly create diverse libraries of compounds. It involves the reaction of an amine, an aldehyde, a carboxylic acid and an isonitrile typically in methanol at room temperature. The Ugi reaction has often been used as a tool in the synthesis of pharmacologically active molecules. It has been observed that Ugi products sometimes precipitate in pure form from the reaction mixture. This is a very fortunate outcome since the reaction can then be easily scaled up without requiring costly purification procedures such as chromatography. It would be most beneficial to optimize the Ugi product yield as obtained directly from filtering the reaction mixture without further treatment. To this end we utilized a... Tipo: Manuscript Palavras-chave: Chemistry; Pharmacology. Ano: 2008 URL: http://precedings.nature.com/documents/2237/version/1 Reaction Attempts Book Nature Precedings Jean-Claude Bradley; Khalid Mirza; Andrew Lang; Tim Bohinski; David Bulger; Alisha Merchant; Emily Messner; Marshall Moritz; Shannon Oseback; Rikesh Parikh; Mitesh Shah. This book is a compilation of Ugi reactions attempted for the UsefulChem Project mainly in the Bradley laboratory at Drexel University. This includes failed, inconclusive or in progress reactions as well as those where a product was successfully isolated and characterized. The entries are sorted alphabetically based on reactants. Links are provided to the relevant lab notebook pages. Future editions will include contributions from other sources as well. Tipo: Manuscript Palavras-chave: Chemistry. Ano: 2010 URL: http://precedings.nature.com/documents/4416/version/1 Registros recuperados: 3 Primeira ... 1 ... Última

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