|
|
|
|
|
| Nordestgaard,Børge G; Langsted,Anne; Mora,Samia; Kolovou,Genovefa; Baum,Hannsjörg; Bruckert,Eric; Watts,Gerald F; Sypniewska,Grazyna; Wiklund,Olov; Borén,Jan; Chapman,M. John; Cobbaert,Christa; Descamps,Olivier S; von Eckardstein,Arnold; Kamstrup,Pia R; Pulkki,Kari; Kronenberg,Florian; Remaley,Alan T; Rifai,Nader; Ros,Emilio; Langlois,Michel. |
| Objetivos: Evaluar criticamente las implicaciones clinicas de la utilizacion del perfil lipidico sin ayuno en lugar de perfiles de lipidos con ayuno y proporcionar orientacion para la elaboracion de informes de laboratorio sobre perfiles lipidicos anormales con ayuno y sin ayuno. Metodos y Resultados: Abundantes datos observacionales, en los que perfiles lipidicos medidos aleatoriamente sin ayuno se han comparado con perfiles lipidicos determinados en condiciones de ayuno, indican que las variaciones medias maximas de 1-6 h despues de ingestas habituales no son clinicamente significativas [+0,3 mmol/L (+26 mg/dL) para trigliceridos; -0,2 mmol/L (-8 mg/dL) para colesterol total; -0,2 mmol/L (-8 mg/dL) para colesterol-LDL; +0,2 mmol/L (+8 mg/dL) para... |
| Tipo: Info:eu-repo/semantics/article |
|
| Ano: 2016 |
URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0325-29572016000300016 |
| |
|
|
| Kolovou,Genovefa; Kolovou,Vana; Ragia,Georgia; Mihas,Constantinos; Diakoumakou,Olga; Vasiliadis,Ioannis; Mavrogeni,Sophie; Vartela,Vassiliki; Manolopoulos,Vangelis G. |
| In this work, we examined the impact of polymorphism in the cytochrome P450 (CYP) 3A5 gene, CYP3A5*1 (6986A > G, rs 776746), on the reduction in the lipid levels caused by simvastatin and atorvastatin. We studied 350 hyperlipidemic patients who received 10-40 mg of atorvastatin (n = 175) or simvastatin (n = 175) daily. Genotyping for CYP3A5 was done by PCR-RFLP analysis. Differences in the lipid profile before and after treatment were expressed as the % difference. The frequency of CYP3A5 polymorphism was 13.4% for heterozygotes and 86.6% for homozygotes. Comparison of the responses to same dose of each drug showed that the highest % difference was associated with total cholesterol (TC) in subjects receiving atorvastatin 40 mg compared with simvastatin... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Atorvastatin; Cholesterol; CYP3A5 gene polymorphism; Simvastatin. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572015000200129 |
| |
|
|
|
