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A modelling study of beta-amyloid induced change in hippocampal theta rhythm Nature Precedings
Xin Zou; Damien Coyle; KongFatt Wong-Lin; Liam Maguire.
Many dementia cases, such as Alzheimer’s disease (AD), are characterized by an increase in low frequency field potential oscillations. However, a definitive understanding of the effects of the beta-Amyloid peptide, which is a main marker of AD, on the low frequency theta rhythm (4-7Hz) is still unavailable. In this work, we investigate the neural mechanisms associated with beta-Amyloid toxicity using a conductance-based neuronal network model of the hippocampus CA1 region. We simulate the effects of beta-Amyloid on the A-type fast inactivating K+ channel by modulating the maximum conductance of the current in pyramidal cells, denoted by gA. Our simulation results demonstrate that as gA decreases (through A[beta]
blockage), the...
Tipo: Manuscript Palavras-chave: Neuroscience.
Ano: 2011 URL: http://precedings.nature.com/documents/6004/version/1
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