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Maternal age and Down syndrome in Southeastern Brazil Braz. J. Genet.
Beiguelman,Bernardo; Krieger,Henrique; Silva,Luciana Marques da.
The proportion of maternal-age-independent patients estimated among 200 Brazilian Down syndrome children (59.6%) was significantly larger than that of maternal-age-dependent cases (40.4%). The latter proportion is the smallest observed in pertinent literature and due basically to the low mean maternal age of the population analyzed. Based on the remarkable correlation (r = 0.95) between the proportion of maternal-age-dependent patients and the mean maternal age of the general population, a simple predictive equation to estimate the proportion of maternal-age-dependent Down syndrome patients based on the mean maternal age of the general population is suggested in situations where reliable data on the incidence of this syndrome according to maternal age is...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Maternal age; Down syndrome; Southeastern Brazil.
Ano: 1996 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-84551996000400020
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Birth weight of twins: 1. The fetal growth patterns of twins and singletons Genet. Mol. Biol.
Beiguelman,Bernardo; Colletto,Gloria M.D.D.; Franchi-Pinto,Carla; Krieger,Henrique.
Distributions of birth weights of twins and singletons born at three southeastern Brazilian hospitals were compared after adjustment for gestational age, its quadratic and cubic terms, sex, type of pregnancy, as well as their interactions. The pattern of twin fetal growth rate was retarded in comparison to that of singletons, regardless of the socioeconomic level of the examined population, but the gestational age at which this retardation started seems to be correlated to the income of the mothers. In all cases, after 28 weeks of gestation, female fetal growth was slightly but consistently lower than that of males.
Tipo: Info:eu-repo/semantics/article
Ano: 1998 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47571998000100025
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Genetic causes involved in Leishmania Chagasi infection innortheastern: Brazil Genet. Mol. Biol.
Feitosa,Mary Furlan; Azevêdo,Eliane; Lima,Ângela Maria; Krieger,Henrique.
A sample of 502 individuals from 94 families from Jacobina, State of Bahia, Brazil, was investigated to determine the causal mechanisms involved in Leishmania chagasi (the causal agent of visceral leishmaniasis in the American hemisphere) infection, as measured by the intradermic reaction to antigens derived from this parasite, using complex segregation analyses. The results showed evidence of a major genetic mechanism acting on infection, with a frequency of a recessive (or additive) susceptibility gene (q) of approximately 0.45. A small multifactorial component (H = 0.29) acting in conjunction with a major recessive gene (q = 0.37) is not ruled out as a concomitant causative factor.
Tipo: Info:eu-repo/semantics/article
Ano: 1999 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47571999000100001
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Evidence for biological inheritance of the eosinophil response to internal parasites in southeastern Brazil Genet. Mol. Biol.
Conti,Fátima; Dal' Colletto,Glória M. Duccini; Feitosa,Mary Furlan; Krieger,Henrique.
One hundred and seventy-seven individuals belonging to 120 complete or incomplete nuclear families from Bambui, in the State of Minas Gerais, southeastern Brazil, were studied in order to examine causes of variation in the eosinophil rate among subjects infested by intestinal worms with an extra-digestive cycle. Segregation analysis without correction for skewness showed that the hypothesis of the presence of an additive major gene was consistent with the data, although a dominant, recessive, or a multifactorial hypothesis could not account properly for the observed significant familial aggregation. The most parsimonious correction for skewness showed similar results, but could not distinguish between dominant and recessive models, although co-dominance...
Tipo: Info:eu-repo/semantics/article
Ano: 1999 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47571999000400004
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Birth weight of twins: 2. Fetal genetic effect on birth weight Genet. Mol. Biol.
Beiguelman,Bernardo; Colletto,Glória M.D.D.; Franchi-Pinto,Carla; Krieger,Henrique.
Intraclass correlation coefficients were calculated for the birth weights of twins born at three southeastern Brazilian hospitals, after adjustment of the natural logarithms of these weights for gestational age, its quadratic and cubic terms, sex, and their interactions. The data indicate that fetal genetic effect on birth weight might have the opportunity to be demonstrated by children born to undernourished women. Undernourishment, acting as a selective force, might enhance the existence of genotypes that determine less need of food for normal development.
Tipo: Info:eu-repo/semantics/article
Ano: 1998 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47571998000100026
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Bernardo Beiguelman (1932-2010) Genet. Mol. Biol.
Krieger,Henrique; Pinto Jr,Walter.
Tipo: Info:eu-repo/semantics/other
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572011000200001
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Genetic effect on apgar score Genet. Mol. Biol.
Franchi-Pinto,Carla; Colletto,Glória Maria Duccini Dal; Krieger,Henrique; Beiguelman,Bernardo.
Intraclass correlation coefficients for one- and five-min Apgar scores of 604 twin pairs born at a southeastern Brazilian hospital were calculated, after adjusting these scores for gestational age and sex. The data support a genetic hypothesis only for 1-min Apgar score, probably because it is less affected by the environment than 4 min later, after the newborns have been under the care of a neonatology team. First-born twins exhibited, on average, better clinical conditions than second-born twins. The former showed a significantly lower proportion of Apgar scores under seven than second-born twins, both at 1 min (17.5% vs. 29.8%) and at 5 min (7.2% vs. 11.9%). The proportion of children born with "good" Apgar scores was significantly smaller among twins...
Tipo: Info:eu-repo/semantics/article
Ano: 1999 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47571999000100003
Registros recuperados: 7
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