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| Kuzmina, N.; Ellison, J.; Orciari, L.; Marissen, W.; Kuzmin, I.; Rupprecht, C.. |
| The demand for rabies immune globulin (RIG) for post-exposure prophylaxis (PEP) is significant. Unfortunately, the cost of RIG is prohibitive for many patients in developing countries. Several monoclonal antibodies (MAbs) which neutralize rabies virus (RABV) have been proposed as a replacement for conventional RIG due to the ability of their large-scale production at a reduced cost. In the present study, we generated 487 RABV glycoprotein (G) sequences from a variety of viral lineages, and supplemented the dataset with 154 complete and 115 partial G sequences available in GenBank. The objective was to evaluate variability of known MAb-binding epitopes on the G, which may preclude virus neutralization. The analysis demonstrated that binding site of MAb CR57... |
| Tipo: Info:eu-repo/semantics/article |
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| Ano: 2013 |
URL: http://www.revistamvez-crmvsp.com.br/index.php/recmvz/article/view/247 |
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| Osinubi, M. O. V.; Recuenco, S.; Kuzmin, I.; Haberling, D. L.; Blau, D. M.; Davis, L. B.; Ehimiyein, A. M.; Ogunkoya, A. B.; Rupprecht, C.. |
| Among the currently recognized species in the Lyssavirus genus worldwide, all but one (Mokola virus) has been identified in bats. Recent discovery of emerging pathogens of zoonotic importance in bats raises concerns about health risks of populations that directly or indirectly come in contact with these diverse mammals. Idanre, an ancient city situated in Southwest Nigeria, conducts a unique bat festival twice annually, where the populations have traditional practices that involve capturing and consuming bats. These activities bring them into direct contact with bats that are important not only because of potential exposure to lyssaviruses, but also to other emerging pathogens. A knowledge, attitude and practices survey was developed and administered to... |
| Tipo: Info:eu-repo/semantics/article |
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| Ano: 2013 |
URL: http://www.revistamvez-crmvsp.com.br/index.php/recmvz/article/view/3165 |
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