|
|
|
|
|
| Monteiro,Lis Marie; Tavares,Guilherme Diniz; Ferreira,Elizabeth Igne; Consiglieri,Vladi Olga; Bou-Chacra,Nadia Araci; Löbenberg,Raimar. |
| Hydroxymethylnitrofurazone (NFOH) is a new compound with potential leishmanicidal and trypanocidal activity. Despite its effectiveness, the formulators have to overcome its poor aqueous solubility. Recently, polymeric nano-scale drug delivery systems have proposed for the treatment of neglected diseases. As several studies have confirmed the advantages of such formulations, and this approach provides new analytical challenges, including the need to detect trace amounts of the drug. A suitable method was developed and validated for NFOH determination bound to poly (n-butylcyanoacrylate) (PBCA) nanoparticles. The chromatographic separation was achieved using a C18 column maintained at 25 ºC and an isocratic mobile phase consisting of water and acetonitrile:... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Hydroxymethylnitrofurazone/determinação; Nanoparticle; High-performance liquid chromatography/reverse phase/quantitative analysis; Poly(n-butylcyanoacrylate)/nanoparticles/encapsulation. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502015000300561 |
| |
|
|
| Zuo,Jieyu; Zhang,Wugang; Jian,Hui; Bou-Chacra,Nádia; Löbenberg,Raimar. |
| Traditional Chinese Herbal Medicine has been used to prevent and cure disease in China for thousands of years and has gained global interest in recent decades. The Erding formula is a Chinese Pharmacopeia (ChP)-listed herbal preparation used for treating sore throat, carbuncles and boils. Esculetin is a ChP quality control (QC) marker for these indications. A previous study found that a new indication, hyperuricemia, can be added to the Erding formula. Therefore, this study aimed to evaluate whether the traditionally used marker, esculetin, still has bioactivity for hyperuricemia, which is substantially different from the original indications. The study analyzed the quantity of esculetin by high-performance liquid chromatography, assessed the therapeutic... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Esculetin; Erding granules; Traditional Chinese Herbal Medicine; Bioactive marker. |
| Ano: 2020 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100518 |
| |
|
| |
|
|
|
