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| CJ,Fecchio; LA,Dias-Melicio; AMVC,Soares; S,Guimarães; MTS,Peraçoli; A,Sartori. |
| Cell-free antigens (CFAg) derived from Paracoccidioides brasiliensis have typically been used in immunodiffusion reactions for serodiagnosis or therapeutic follow-up of paracoccidioidomycosis patients. Thus, we investigated the usefulness of CFAg obtained from cultures at different ages, to evaluate cellular immunity by the footpad test, in experimental murine paracoccidioidomycosis. Male mice infected with P. brasiliensis 265 strain were challenged in the footpad with CFAg obtained from four- (4d CFAg) or 11-day-old cultures (11d CFAg). The increase in footpad swelling provoked by 4d CFAg and 11d CFAg was similar and showed significant difference in relation to control groups. However, the infiltrate pattern was strikingly different: 4d CFAg induced a... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Paracoccidioides brasiliensis; Cell-free antigens; Delayed-type hypersensitivity reaction; Gp43; Murine paracoccidioidomycosis. |
| Ano: 2011 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992011000300012 |
