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| HOU,LIJUAN; LI,KE; HU,YANRU; BIAN,YIJUN; JI,WEI; SHI,KAIXUAN; LI,YITING; CHEN,MENGJIAO; LI,JIAXIN; LIU,XIAOLI; QIAO,DECAI. |
| Abstract: The mechanism behind exercise-induced fatigue is a significant topic in the field of sports physiology. Therefore, establishing and evaluating an acute exercise-induced fatigue animal model that explores the limits of the motor system may provide greater insight into these mechanisms. Heart rate is an important quantitative parameter that accurately reflects the immediate change in physical function due to exercise load. And there is likely to be an important correlation between heart rate and behavioral performance. In this study, changes in heart rate and behavioral indexes during exercise-induced fatigue were quantitatively analyzed in rats using heart rate telemetry and video methods respectively. The behavioral indexes were used as... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Exercise-induced fatigue; Animal model; Treadmill running; Heart rate. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000700624 |
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| LI,KE; SHU,XUAN; GONG,HUI; CHENG,LIUHANGHANG; DONG,ZEJUN; SHU,SHENYOU. |
| Abstract: DNA methylation is essential for spatiotemporally-regulated gene expression in embryonic development. TBX22 (Chr X: 107667964-107688978) functioning as a transcriptional repressor affects DNA binding, sumoylation, and transcriptional repression associated with X-linked cleft palate. This study aimed to explore the relationship and potential mechanism between TBX22 exon 5 methylation and palatal shelf fusion induced by all-trans retinoic acid (ATRA). We performed DNA methylation profiling, using MethylRAD-seq, after high throughput sequencing of mouse embryos from control (n=9) and ATRA-treated (to induce cleft palate, n=9) C57BL/6J mice at embryonic gestation days(E) 13.5, 14.5 and 16.5. TBX22 exon 5 was hyper-methylated at the CpG site at... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: DNA methylation; Cleft palate; TBX22; CpG site. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000300711 |
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