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| SILVA,Germana Michelle de Medeiros e; BEZERRA,Raquel Pedrosa; TEIXEIRA,José António; SILVA,Flávio Oliveira; CORREIA,Juliana Mendes; PORTO,Tatiana Souza; LIMA-FILHO,José Luis; PORTO,Ana Lúcia Figueiredo. |
| ABSTRACT Thrombosis is a pathophysiological disorder caused by accumulation of fibrin in the blood. Fibrinolytic proteases with potent thrombolytic activity have been produced by diverse microbial sources. Considering the microbial biodiversity of the Amazon region, this study aimed at the screening, production and biochemical characterization of a fibrinolytic enzyme produced by Streptomyces sp. isolated from Amazonian lichens. The strain Streptomyces DPUA1576 showed the highest fibrinolytic activity, which was 283 mm2. Three variables at two levels were used to assess their effects on the fibrinolytic production. The parameters studied were agitation (0.28 - 1.12 g), temperature (28 - 36 ºC) and pH (6.0 - 8.0); all of them had significant effects on the... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Actinomycetes; Fibrinolytic protease; Inhibitor protease; Fibrinogenolytic activity. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0044-59672016000300323 |
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