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	Provedor de dados J. Venom. Anim. Toxins incl. Trop. Dis. (3) Autor Laraba-Djebari,Fatima (3) Hammoudi-Triki,Djelila (2) Adi-Bessalem,Sonia (1) Béchohra,Louisa (1) Chérifi,Fatah (1) Saidi,Hadjer (1) Mais... Palavra-chave Aah venom (1) Acetylcholine (1) Apoptosis (1) Atropine (1) Blood-clotting (1) Cerastes cerastes venom (1) Cytokines (1) Cytotoxicity (1) F3 fraction (1) Hemostasis (1) Lung cancer cells (1) Lung inflammation (1) Oxidative stress (1) Phospholipases A2 (1) Platelets (1) Propranolol (1) Proteinases (1) Scorpion venoms (1) Mais... Tipo do documento Info:eu-repo/semantics/article (3) Ano 2016 (1) 2013 (2) País Brazil (3) Idioma Inglês (3)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 3 Primeira ... 1 ... Última Cytotoxic activity of Androctonus australis hector venom and its toxic fractions on human lung cancer cell line J. Venom. Anim. Toxins incl. Trop. Dis. Béchohra,Louisa; Laraba-Djebari,Fatima; Hammoudi-Triki,Djelila. Abstract Background: Several studies have showed that animal venoms are a source of bioactive compounds that may inhibit the growth of cancer cells, which makes them useful agents for therapeutic applications. Recently, it was established that venom toxins from scorpions induced cytotoxic, antiproliferative and apoptogenic effects on cancer cells. Therefore, the present study aims to investigate the cytotoxic activity of Androctonus australis hector (Aah) scorpion venom and its toxic fractions (FtoxG-50 and F3) on NCI-H358 human lung cancer cells. Methods: The cytotoxic and antiproliferative activities were estimated using MTT assay, lactate dehydrogenase release and clonogenic assays. Apoptosis was evaluated by Hoechst 33258 staining, DNA fragmentation... Tipo: Info:eu-repo/semantics/article Palavras-chave: Aah venom; Cytotoxicity; F3 fraction; Apoptosis; Lung cancer cells; Oxidative stress. Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992016000100322 Isolated biomolecules of pharmacological interest in hemostasis from Cerastes cerastes venom J. Venom. Anim. Toxins incl. Trop. Dis. Chérifi,Fatah; Laraba-Djebari,Fatima. Biomolecules from Cerastes cerastes venom have been purified and characterized. Two phospholipases isolated from Cerastes cerastes venom share 51% of homology. CC2-PLA2 exhibits antiplatelet activity that blocks coagulation. CCSV-MPase, a non-hemorrhagic Zn2+-metalloproteinase, significantly reduced the plasmatic fibrinogen level and hydrolyzes only its Bβ chain. Serine proteinases such as RP34, afaâcytin and CC3-SPase hydrolyze the fibrinogen and are respectively α, αβ and αβ fibrinogenases. In deficient human plasma, afaâcytin replaces the missing factors VIII and IX, and activates purified human factor X into factor Xa. It releases serotonin from platelets and directly aggregates human (but not rabbit) blood platelets. RP34 proteinase also had no effect... Tipo: Info:eu-repo/semantics/article Palavras-chave: Cerastes cerastes venom; Proteinases; Phospholipases A2; Platelets; Blood-clotting; Hemostasis. Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992013000100201 Effects of atropine and propranolol on lung inflammation in experimental envenomation: comparison of two buthidae venoms J. Venom. Anim. Toxins incl. Trop. Dis. Saidi,Hadjer; Adi-Bessalem,Sonia; Hammoudi-Triki,Djelila; Laraba-Djebari,Fatima. Background Previous works had shown that scorpion venom induced neurotransmitter elevation and an inflammatory response associated with various anatomo-pathological modifications. The most dangerous scorpions species in Algeria responsible for these effects are Androctonus australis hector (Aah) and Androctonus amoreuxi (Aam). Results Comparison of the physiopathological effects induced by the two venoms showed differences in the kinetic of cytokine release and in lung injury. The lung edema was only observed in response to Aah venom and it was correlated with cell infiltration. In order to better understand the involved mechanism in inflammatory response, we used two antagonists, atropine (non-selective muscarinic antagonist) and propranolol (β adrenergic... Tipo: Info:eu-repo/semantics/article Palavras-chave: Scorpion venoms; Cytokines; Lung inflammation; Acetylcholine; Atropine; Propranolol. Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992013000100305 Registros recuperados: 3 Primeira ... 1 ... Última

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