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	Provedor de dados BJMBR (4) Autor Laurindo,F.R.M. (4) Carvalho,M.H.C. (2) Augusto,O. (1) Barbeiro,H.V. (1) Bassi,E. (1) Bortolotto,L.A. (1) Dantas,A.P.V. (1) Francisco,Y.A. (1) Krieger,J.E. (1) Liberman,M. (1) Martinatti,M.K. (1) Miyakawa,A.A. (1) Pedro,M.A. (1) Pertrini,C.M. (1) da-Luz,P.L. (1) Mais... Palavra-chave Nitric oxide (2) Angiotensin-I converting enzyme (1) Antioxidants (1) Arginine analogues (1) Atherosclerosis (1) Endothelial cells (1) Endothelial function (1) Estrogen (1) Free radicals (1) Lipoic acid (1) NG-methyl-D-arginine (1) NG-methyl-L-arginine (1) NG-nitro-L-arginine methyl ester (1) Oxidative stress (1) Restenosis post-angioplasty (1) Shear stress (1) Vascular calcification (1) Vascular remodeling (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Info:eu-repo/semantics/other (2) Ano 2014 (1) 2005 (1) 2003 (1) 1998 (1) País Brazil (4) Idioma Inglês (4)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 4 Primeira ... 1 ... Última Nonspecific blockade of vascular free radical signals by methylated arginine analogues BJMBR Pedro,M.A.; Augusto,O.; Barbeiro,H.V.; Carvalho,M.H.C.; da-Luz,P.L.; Laurindo,F.R.M.. Methylated arginine analogues are often used as probes of the effect of nitric oxide; however, their specificity is unclear and seems to be frequently overestimated. This study analyzed the effects of NG-methyl-L-arginine (L-NMMA) on the endothelium-dependent release of vascular superoxide radicals triggered by increased flow. Plasma ascorbyl radical signals measured by direct electron paramagnetic resonance spectroscopy in 25 rabbits increased by 3.8 ± 0.7 nmol/l vs baseline (28.7 ± 1.4 nmol/l, P&lt;0.001) in response to papaverine-induced flow increases of 121 ± 12%. In contrast, after similar papaverine-induced flow increases simultaneously with L-NMMA infusions, ascorbyl levels were not significantly changed compared to baseline. Similar results... Tipo: Info:eu-repo/semantics/article Palavras-chave: Free radicals; Arginine analogues; NG-methyl-L-arginine; NG-methyl-D-arginine; NG-nitro-L-arginine methyl ester. Ano: 1998 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000600004 Lipoic acid, but not tempol, preserves vascular compliance and decreases medial calcification in a model of elastocalcinosis BJMBR Bassi,E.; Liberman,M.; Martinatti,M.K.; Bortolotto,L.A.; Laurindo,F.R.M.. Vascular calcification decreases compliance and increases morbidity. Mechanisms of this process are unclear. The role of oxidative stress and effects of antioxidants have been poorly explored. We investigated effects of the antioxidants lipoic acid (LA) and tempol in a model of atherosclerosis associated with elastocalcinosis. Male New Zealand white rabbits (2.5-3.0 kg) were fed regular chow (controls) or a 0.5% cholesterol (chol) diet+104 IU/day vitamin D2 (vitD) for 12 weeks, and assigned to treatment with water (vehicle, n=20), 0.12 mmol·kg-1·day-1 LA (n=11) or 0.1 mmol·kg-1·day-1 tempol (n=15). Chol+vitD-fed rabbits developed atherosclerotic plaques associated with expansive remodeling, elastic fiber disruption, medial calcification, and increased... Tipo: Info:eu-repo/semantics/article Palavras-chave: Antioxidants; Vascular calcification; Atherosclerosis; Oxidative stress; Lipoic acid. Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2014000200119 Nitric oxide regulates angiotensin-I converting enzyme under static conditions but not under shear stress BJMBR Pertrini,C.M.; Miyakawa,A.A.; Laurindo,F.R.M.; Krieger,J.E.. Mechanical forces including pressure and shear stress play an important role in vascular homeostasis via the control of the production and release of a variety of vasoactive factors. An increase in vascular shear stress is accompanied by nitric oxide (NO) release and NO synthase activation. Previously, we have demonstrated that shear stress induces angiotensin-I converting enzyme (ACE) down-regulation in vivo and in vitro. In the present study, we determined whether NO participates in the shear stress-induced ACE suppression response. Rabbit aortic endothelial cells were evaluated using the NO synthase inhibitor L-NAME, and two NO donors, diethylamine NONOate (DEA/NO) and sodium nitroprusside (SNP). Under static conditions, incubation of endothelial cells... Tipo: Info:eu-repo/semantics/other Palavras-chave: Shear stress; Angiotensin-I converting enzyme; Nitric oxide; Endothelial cells. Ano: 2003 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000900005 Estrogen enhances vasoconstrictive remodeling after injury in male rabbits BJMBR Francisco,Y.A.; Dantas,A.P.V.; Carvalho,M.H.C.; Laurindo,F.R.M.. The complete spectrum of estrogen vascular effects remains unclear. In particular, estrogen effects in the vascular response to profound injury in males have not been explored in detail. Therefore, we submitted 44 male New Zealand rabbits weighing 3.4 ± 0.6 kg to overdistention balloon injury of the right iliac artery. Rabbits were given 17ß-estradiol (5.45 µmol/day, sc) or vehicle for 7 days before and 14 days after injury, when the arteries were examined by post-mortem histomorphometry. Arteriographic caliber was assessed in vivo at baseline and before sacrifice. On day 14 after injury, in vivo arteriographic caliber (baseline = 2.44 ± 0.43 mm) was decreased by 23.1 ± 0.1% in controls and by 44.5 ± 0.1% in estrogen-treated rabbits (P < 0.001). Neither... Tipo: Info:eu-repo/semantics/other Palavras-chave: Estrogen; Restenosis post-angioplasty; Nitric oxide; Endothelial function; Vascular remodeling. Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000900006 Registros recuperados: 4 Primeira ... 1 ... Última

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