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	Provedor de dados BJPS (1) Autor Araújo,Magali Benjamin de (1) Bonfilio,Rudy (1) Doriguetto,Antônio Carlos (1) Leal,Jockastta Silva (1) Souza,Marília Cristina Oliveira (1) Viana,Olímpia Maria Martins Santos (1) Mais... Palavra-chave Dissolution/analysis (1) Infrared spectroscopy/methods (1) Powder X-ray diffraction/methods (1) Solubility/drug effects (1) Tibolone/polymorphs (1) Tipo do documento Info:eu-repo/semantics/article (1) Ano 2017 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Solubility and dissolution studies of tibolone polymorphs BJPS Bonfilio,Rudy; Souza,Marília Cristina Oliveira; Leal,Jockastta Silva; Viana,Olímpia Maria Martins Santos; Doriguetto,Antônio Carlos; Araújo,Magali Benjamin de. ABSTRACT Different solid forms of an active pharmaceutical ingredient can have distinct chemical and physical characteristics. In this work, we studied the solubility and dissolution properties of the described tibolone polymorphic forms (I and II). Both forms were successively recrystallized and characterized by powder X-ray diffraction and attenuated total reflection infrared spectroscopy. Equilibrium solubility and dissolution profiles were performed for both forms. Solubility studies demonstrated that form II is statistically more soluble in water, 0.01 mol L-1 HCl and pH 4.5 acetate buffer. The solubility of forms I and II were explained in terms of crystal packing. Dissolution tests of tablets showed a lower release of polymorphic form II than form I... Tipo: Info:eu-repo/semantics/article Palavras-chave: Tibolone/polymorphs; Powder X-ray diffraction/methods; Infrared spectroscopy/methods; Solubility/drug effects; Dissolution/analysis. Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000400607 Registros recuperados: 1 Primeira ... 1 ... Última

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