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| Mariotti,Kristiane de Cássia; Barreto,Fabiano; Schmitt,Gabriela Cristina; Zancanaro,Ivomar; Dallegrave,Eliane; Singer,Rodrigo Bustos; Leal,Mirna Bainy; Limberger,Renata Pereira. |
| Gunnera (Gunneraceae) forms a complex association with the cyanobacterium Nostoc puctiforme L. Gunnera-Nostoc symbiosis is the only one reported involving a flowering plant, and results in the formation of the neurotoxic amino acid β-N-methylamino-L-alanine (BMAA). The species Gunnera manicata L., for which phytochemical, pharmacological and toxicological studies are lacking, is found in Southern Brazil. Therefore, acute toxicity and the presence of neurotoxic amino acid were investigated in aqueous extracts of G. manicata. The acute toxicity test was conducted by administering aqueous root extract of G. manicata at a concentration of 2000 mg/kg in a single dose orally to Wistar rats. Lethality was monitored daily for 14 days after treatment. The relative... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Gunnera manicata L; /toxicity; Β-N-methylamino-L-alanine/identification; Neurotoxins/identification; Acute toxicity. |
| Ano: 2011 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502011000300021 |
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| Mariotti,Kristiane de Cássia; Schmitt,Gabriela Cristina; Barreto,Fabiano; Fortunato,Rodrigo E.; Singer,Rodrigo B.; Dallegrave,Eliane; Leal,Mirna Bainy; Limberger,Renata Pereira. |
| Gunnera perpensa (Gunneraceae) is an African plant widely used in traditional medicine. This species is known for its activity involving the female reproductive system, such as inducing or increasing labor, treating female infertility, expelling the placenta and/or preventing post-partum hemorrhage. These properties are probably due to (z)-venusol, a majoritary compound, and its action in conjunction with substances in the whole extract and other natural products. In southern Brazil, a native species Gunnera manicata L. that also belongs to Gunneraceae can be found. In spite of the traditional use of G. perpensa, there is no pharmacological and phytochemical information regarding the South American Gunnera species. Therefore, the aim of this study was to... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Gunnera manicata L./pharmacognosy; Gunneraceae/pharmacognosy; Medicinal plants; Uterotrophic assay/experimental study. |
| Ano: 2011 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502011000300018 |
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| Schmitt,Gabriela Cristina; Arbo,Marcelo Dutra; Lorensi,Andréia Louise; Jacques,Ana Laura Bemvenuti; Nascimento,Sabrina Nunes do; Mariotti,Kristiane de Cássia; Garcia,Solange Cristina; Dallegrave,Eliane; Leal,Mirna Bainy; Limberger,Renata Pereira. |
| ABSTRACT The association of p-synephrine, ephedrine, salicin, and caffeine in dietary supplements and weight loss products is very common worldwide, even though ephedrine has been prohibited in many countries. The aim of this study was to evaluate a 28-day oral exposure toxicity profile of p-synephrine, ephedrine, salicin, and caffeine mixture (10:4:6:80 w/w respectively) in male and female Wistar rats. Body weight and signs of toxicity, morbidity, and mortality were observed daily. After 28 days, animals were euthanized and blood collected for hematological, biochemical, and oxidative stress evaluation. No clinical signs of toxicity, significant weight loss or deaths occurred, nor were there any significant alterations in hematological parameters.... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: P-Synephrine/toxicity profile; Ephedrine/toxicity profile; Salicin/toxicity profile; Caffeine/toxicity profile; Dietary supplements/evaluation; Weight loss products/evaluation.. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502016000100007 |
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| Arbo,Marcelo Dutra; Braun,Paulini; Leal,Mirna Bainy; Larentis,Elisa Raup; Aboy,Ana Lucia; Bulcão,Rachel Picada; Garcia,Solange Cristina; Limberger,Renata Pereira. |
| Citrus aurantium (bitter orange) is characterized by the presence of p-synephrine, an amine structurally and pharmacologically related to ephedrine. Besides the same adverse effects as ephedrine, nowadays it is believed that altered levels of p-synephrine can be associated to the occurrence of migraine and cluster headaches. Leaves and fruits of this species are highly commercialized in form of teas and herbal preparations, but without taking into account the risks associated with its use. This work describes a survey of teas and herbal preparations containing C. aurantium, commercialized in Porto Alegre (RS/Brazil), in order to verify the presence of p-synephrine. Comparing with the mean amount available in the supermarkets, around 20% of the teas and 10%... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Citrus aurantium; P-synephrine/adverse effects; Bitter orange; Teas/analysis. |
| Ano: 2009 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502009000200012 |
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