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| Registros recuperados: 12 | |
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| Lacerda Lopes Martins,Monica; Endringer Pinto,Fernanda; Uggere de Andrade,Tadeu; Lenz,Dominik; Costa Pereira,Thiago de Melo; Coutinho Endringer,Denise. |
| Introduction: species of the family Cyperaceae are commonly used by the population to treat gastric disorders.However, there are a few ethnopharmacological studies about this family Lagenocarpus rigidus (Kunth) Ness, Cyperaceae, is one of the most widespread swamp species. Objective: evaluate the gastric activity of L. rigidus and its chemical characterization. Methods: ethanolic extract of L. rigidus (ELR) leaves prepared by percolation was subjected to total polyphenol and flavonoid quantification, as well as HPLC quantification of some flavonoids. Angiotensin converting enzyme (ACE) inhibition was determined by colorimetric assays.The gastric effects of ELR were tested in male Wistar rats (n = 6 each group) treated with different doses (600, 60 and 6... |
| Tipo: Journal article |
Palavras-chave: Cyperaceae anti-ulcerogenic flavonoids; L rigidus phenolic compound. |
| Ano: 2014 |
URL: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1028-47962014000200001 |
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| Marchiori Mariani,Paula; Da Rós Freitas,Paula; Carneiro Kalil,Iêda; Alexandre Brasil,Girlandia; Nascimento Ronchi,Silas; Lenz,Dominik; Aires Ventura,José; Uggere De Andrade,Tadeu; Coutinho Endringer,Denise. |
| Introdução: os frutos de Carica papaya L. são amplamente consumidos em todo o mundo e no Brasil, porém pouco se sabe sobre seu efeito citotóxico, antimutagênico e quimioprotetor. Objetivos: avaliar o potencial antimutagênico e quimiprotetor de frutos de Carica papaya e quantificar as suas substâncias fenólicas. Métodos: a atividade antimutagênica foi avaliada pelo método de micronúcleo e as substâncias fenólicas foram analisadas pelo método de Folin-Ciacalteau (fenólicos totais), e pelo método colorimétrico cloreto de alumínio (flavonóides totais). Resultados: o extrato hidroetanólico de frutos de Carica papaya possui potencial antimutagênico e quimioprotetor (370 mg/100 g peso corporal). O teor de substâncias fenólicas do extrato hidroetanólico de frutos... |
| Tipo: Journal article |
Palavras-chave: Carica papaya L.; Teste do micronúcleo; Compostos fenólicos. |
| Ano: 2013 |
URL: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1028-47962013000300006 |
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| Cardoso,Priscylla Maria Martins; Mazuco,Renata Alves; Macedo,Lucas Soares Dazzi; Polese,Ariele Abreu Venturini; Barroso,Maria Eduarda de Souza; Baratella,Waléria Gramilich; Andrade,Tadeu Uggere de; Lenz,Dominik; Pereira,Thiago de Melo Costa; Endringer,Denise Coutinho. |
| Contrast-induced nephropathy (NIC) is directly related to increased morbidity and mortality, and its treatment and prevention might be achieved by the administration of antioxidant products. The juçara palmetto (Euterpe edulis Martius) has fruits rich in phenolic compounds, which are known for their antioxidant activity. This work aimed to evaluate the nephroprotective activity of E. edulis pulp in the NIC animal model. The collected fruits were pulped, their contents of polyphenols and anthocyanins were quantified, and their antioxidant activity were evaluated. The nephroprotective effects were determined based on iodine contrast induction and evaluated by biochemical and histological analyses. The results showed that E. edulis pulp was rich in... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Nephroprotection; Euterpe edulis Martius; Polyphenols; Anthocyanins; Antioxidant activity. |
| Ano: 2020 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100522 |
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| Andrade,Tadeu Uggere de; Barbosa,Jaqueliny Louback da Cunha; Laignier,Lívia Lopes Moura; Mata,Elizangela Faustino da; Cassaro,Karla Oliveira dos Santos; Lenz,Dominik; Sampaio,Karla Nivea; Boëchat,Giovanna Assis Pereira; Endringer,Denise Coutinho. |
| The aim of this study was to estimate the evolution of the field of Pharmaceutical Care (PC) by measuring the quality and quantity of the scientific production on the topic of PC in Brazil compared to two pioneering countries in the field, the United States of America (USA) and Spain. The databases Web of Science, Scopus, Medline, Lilacs and SciELO were used as sources for the literature search. Pharmaceutical Care, or the appropriate translations, was used as the search term for the literature search, which was limited to articles published between 1990 and 2009. A score of quality (SQ) was calculated using variables such as impact factor and the frequency of the citations. We included 3265 articles published in 544 journals. We found that there was a... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Pharmaceutical care/scientific production; Brazil/pharmaceutical care; Brazil/scientific production; Spain/pharmaceutical care; Spain/scientific production; United States of America/pharmaceutical care; United States of America/scientific production. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000100005 |
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| Martins,Monica Lacerda Lopes; Pacheco,Henrique Poltronieri; Perini,Iara Giuberti; Lenz,Dominik; Andrade,Tadeu Uggere de; Endringer,Denise Coutinho. |
| In 1820, French naturalist August Saint Hillaire, during a visit in Espírito Santo (ES), a state in southeastern Brazil, reported a popular use of Cyperaceae species as antidote to snake bites. The plant may even have a hypotensive effect, though it was never properly researched. The in vitro inhibitory of the angiotensin converting enzyme (ACE) activity of eigth ethanolic extracts of Cyperaceae was evaluated by colorimetric assay. Total phenolic and flavonoids were determined using colorimetric assay. The hypotensive effect of the active specie (Rhychonospora exaltata, ERE) and the in vivo ACE assay was measured in vivo using male Wistar Kyoto (ERE, 0.01-100mg/kg), with acetylcholine (ACh) as positive control (5 µg/kg, i.v.). The evaluation of ACE in vivo... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Cyperaceae/species; Cyperaceae/pharmacognosy; Cyperaceae/species; Cyperaceae/in vitro inhibitory activity; Cyperaceae/species; Cyperaceae/in vivo hypotensive effect; Angiotensin converting enzyme/in vitro inhibitory; Flavonoids/determination. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000400020 |
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| Cassaro,Karla Oliveira dos Santos; Heringer,Otávio Arruda; Fronza,Márcio; Lenz,Dominik; Endringer,Denise Coutinho; Andrade,Tadeu Uggere de. |
| ABSTRACT The aim of this study was to evaluate the level of satisfaction of pharmaceutical services and to determine the socioeconomic profile of public pharmacy clients. This is a cross-sectional observational study using a quantitative approach. The sample was calculated from the monthly number of patients seen in pharmacies and was stratified for each pharmacy. Data were analysed using SPSS 11.5 software and by observing the simple relative frequencies for qualitative variables. For the quantitative variables, the analysis of variance (ANOVA) and post-hoc Fisher tests were performed. Data are expressed as mean ± standard deviation (SD). The results show that, in general, patients at "Farmácias cidadãs" are satisfied with the services. However, when... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Public Pharmacy; Unified Health System; Pharmaceutical Services.. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502016000100011 |
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| Mata,Elizângela Faustino Da; Nascimento,Andrews Marques do; Lima,Ewelyne Miranda de; Kalil,Ieda Carneiro; Endringer,Denise Coutinho; Lenz,Dominik; Bissoli,Nazaré Souza; Brasil,Girlandia Alexandre; Andrade,Tadeu Uggere de. |
| Metabolism of anabolic androgenic steroids is important for its physiological effects. The aim was to investigate the effects of finasteride (a 5α-reductase inhibitor - 5αR) on cardiac and mutagenic effects promoted by ND. Male Wistar rats were separated into three groups: CONT, received the vehicles of ND and finasteride (Peanut oil+Saline); DECA group, received ND (20 mg.kg.week-1, i.m.), and DECAF received ND and finasteride (100 µg.kg-1, i.p.), for four weeks. After, hypertrophy, cytokines and Angiotensin Converting Enzyme (ACE) activity was determined in heart. Bone marrow was used for micronucleus evaluation. Treatment with ND promotes increase in cardiac hypertrophy, ACE activity and disbalance among pro- and anti-inflammatory cytokines, and... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Dehydronandrolone; Finasteride; Mutagenicity; Cardiac Hypertrophy; Anabolic Androgenic Steroids. |
| Ano: 2020 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100532 |
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| Silva,Alessandra Tesch da; Lima,Ewelyne Miranda de; Caliman,Isabela Faco; Porto,Leonardo Luiz Souza; Nascimento,Andrews Marques do; Kalil,Iêda Carneiro; Lenz,Dominik; Bissoli,Nazaré Souza; Endringer,Denise Coutinho; Andrade,Tadeu Uggere de. |
| The aims of this study were to evaluate the chemical profile, vascular reactivity, and acute hypotensive effect (AHE) of the ethanolic extract of leaves of Alpinia purpurata (Vieill) K. Schum (EEAP). Its chemical profile was evaluated using HPLC-UV, ICP-OES, and colorimetric quantification of total flavonoids and polyphenols. The vascular reactivity of the extract was determined using the mesenteric bed isolated from WKY. AHE dose-response curves were obtained for both EEAP and inorganic material isolated from AP (IAP) in WKY and SHR animals. Cytotoxic and mutagenic safety levels were determined by the micronucleus test. Rutin-like flavonoids were quantified in the EEAP (1.8 ± 0.03%), and the total flavonoid and polyphenol ratios were 4.1 ± 1.8% and 5.1 ±... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Alpinia; Alpinia purpurata/phytochemistry; Alpinia purpurata/ethanolic extract/vascular reactivity; Alpinia purpurata/ethanolic extract/acute hypotensive effect; Flavonoids/quantification; Polyphenols/quantification. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000200309 |
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| Falquetto,Tânia Cristina; Endringer,Denise Coutinho; Andrade,Tadeu Uggere de; Lenz,Dominik. |
| The aim of the present work was to compare hepatitis C prevalence, genotypes, and risk factors between prisoners and non-prisoners in the city of Colatina, Espírito Santo, Brazil. This cross-sectional study involved approximately 1,600 residents and 730 prisoners, all of whom were living in Colatina. The percentage of individuals who tested positive for anti-HCV was 0.1% (2/1,600) in the non-prisoner group and 1.0% (7/730) in the prisoner group, confirming a higher risk of hepatitis C in the latter group. The percentage of subjects who progressed to HCV-RNA negative was 11.1% (1/9), confirming the high probability of evolution to chronicity. Genotype 1 was the most predominant genotype found. Factors associated with increased risk of hepatitis C were being... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Hepatitis C/prevalence; Hepatitis C/genotypes; Hepatitis C/risk factors; Hepatitis C/symptoms; Anti-HCV; Prison population/risks evaluation. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000400013 |
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| Monteiro,Betânia Souza; Faria,Roberta Delessa; Zanella,Alessandra Rodrigues Coelho; Cruz,Emanuelle Pimentel; Godoi,Noely Pianca; Fiorio,Wagner Alexey Back; Lenz,Dominik; Fortunato,Viviane Raposo. |
| ABSTRACT: To evaluate the therapeutic contribution of MSC intravenous infusion to surgical wound healing in dexamethasone-immunosuppressed rats, thirty-five rats were randomly divided into 2 groups: in the Control Group (CG), five rats received normal saline as 0.2ml subcutaneous (SC) injections every 24 hours, for 30 consecutive days and, in the Dexamethasone Group (DG), 30 rats were given 0.2mL subcutaneous dexamethasone (0.1mg kg-1) every 24 hours, for 30 consecutive days. After 30 days, all rats underwent surgery to create an experimental skin wound. The 30 animals of the DG group were divided into two equal groups, which received different treatments: the dexamethasone group (DG) received a single application of 0.5ml normal saline, via the... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Tissue repair; Cell therapy; Immunomodulation.. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782016001001824 |
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