|
|
|
|
| |
|
|
| Chen,Kai; Wu,Dajiang; Zhu,Xiaodong; Ni,Haijian; Wei,Xianzhao; Mao,Ningfang; Xie,Yang; Niu,Yunfei; Li,Ming. |
| In this study, we used microarray analysis to investigate the biogenesis and progression of intervertebral disc degeneration. The gene expression profiles of 37 disc tissue samples obtained from patients with herniated discs and degenerative disc disease collected by the National Cancer Institute Cooperative Tissue Network were analyzed. Differentially expressed genes between more and less degenerated discs were identified by significant analysis of microarray. A total of 555 genes were significantly overexpressed in more degenerated discs with a false discovery rate of < 3%. Functional annotation showed that these genes were significantly associated with membrane-bound vesicles, calcium ion binding and extracellular matrix. Protein-protein interaction... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Genes; Intervertebral disc degeneration; Molecular classification; Protein-protein interaction. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572013000300021 |
| |
|
|
| Ding,Bo; Wang,Junbin; Song,Na; Li,Ming; Cheng,Qiaolin; Huang,Guozhong; Guo,Yaolin; Fu,Yang; Xie,Chaojie; Sun,Qixin; Xie,Xiaodong. |
| WRKY transcription factors have been extensively characterized in the past 20 years, but in wheat, studies onWRKY genes and their function are lagging behind many other species. To explore the function of wheat WRKY genes, we identified a TaWRKY68 gene from a common wheat cultivar. It encodes a protein comprising 313 amino acids which harbors 19 conserved motifs or active sites. Gene expression patterns were determined by analyzing microarray data of TaWRKY68 in wheat and of orthologous genes from maize, rice and barley using Genevestigator. TaWRKY68 orthologs were identified and clustered using DELTA-BLAST and COBALT programs available at NCBI. The results showed that these genes, which are expressed in all tissues tested, had relatively higher levels in... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Wheat; TaWRKY68; Orthologous genes; Genevestigator; Gene functions. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572014000100013 |
| |
|
|
|
