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Functional changes of dendritic cells in hypersensivity reactions to amoxicillin BJMBR
Lima,C.M.F.; Schroeder,J.T.; Galvão,C.E.S.; Castro,F.M.; Kalil,J.; Adkinson Jr.,N.F..
A better understanding of dendritic cell (DC) involvement in responses to haptenic drugs is needed, because it represents a possible approach to the development of an in vitro test, which could identify patients prone to drug allergies. There are two main DC subsets: plasmacytoid DC (pDC) and myeloid DC (mDC). β-lactams form hapten-carrier conjugates and may provide a suitable model to study DC behavior in drug allergy reactions. It has been demonstrated that drugs interact differently with DC in drug allergic and non-allergic patients, but there are no studies regarding these subsets. Our aim was to assess the functional changes of mDC and pDC harvested from an amoxicillin-hypersensitive 32-year-old woman who experienced a severe maculopapular exanthema...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Dendritic cells; Β-lactam hypersensivity; Plasmacytoid dendritic cells; Drug allergy.
Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010001000007
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