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| Vilar,M.L.L.V.; Frutuoso,M.S.; Arruda,S.M.; Lima,D.M.; Bezerra,C.S.; Pompeu,M.M.L.. |
| The signaling lymphocytic activation molecule (SLAM), present on the surface of hematopoietic cells, can regulate some events of the immune responses. This modulatory action is associated with the capacity of SLAM to interact with an intracytoplasmic adapter, such as SLAM-associated protein (SAP). SLAM is constitutively expressed in most of these cells, is rapidly induced after antigenic or inflammatory stimuli, and participates in the immunological synapse. Defects in the function of the SLAM-SAP pathway contribute to immunological abnormalities, resulting in autoimmune diseases, tumors of the lymphoid tissues and inadequate responses to infectious agents. Initially, the role of SLAM was investigated using an anti-SLAM monoclonal antibody (α-SLAM mAb)... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: SLAM; SAP; IFN-γ; Immunoreceptor; Immunomodulation. |
| Ano: 2011 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000400002 |
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