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| Mata,Elizângela Faustino Da; Nascimento,Andrews Marques do; Lima,Ewelyne Miranda de; Kalil,Ieda Carneiro; Endringer,Denise Coutinho; Lenz,Dominik; Bissoli,Nazaré Souza; Brasil,Girlandia Alexandre; Andrade,Tadeu Uggere de. |
| Metabolism of anabolic androgenic steroids is important for its physiological effects. The aim was to investigate the effects of finasteride (a 5α-reductase inhibitor - 5αR) on cardiac and mutagenic effects promoted by ND. Male Wistar rats were separated into three groups: CONT, received the vehicles of ND and finasteride (Peanut oil+Saline); DECA group, received ND (20 mg.kg.week-1, i.m.), and DECAF received ND and finasteride (100 µg.kg-1, i.p.), for four weeks. After, hypertrophy, cytokines and Angiotensin Converting Enzyme (ACE) activity was determined in heart. Bone marrow was used for micronucleus evaluation. Treatment with ND promotes increase in cardiac hypertrophy, ACE activity and disbalance among pro- and anti-inflammatory cytokines, and... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Dehydronandrolone; Finasteride; Mutagenicity; Cardiac Hypertrophy; Anabolic Androgenic Steroids. |
| Ano: 2020 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100532 |
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| Silva,Alessandra Tesch da; Lima,Ewelyne Miranda de; Caliman,Isabela Faco; Porto,Leonardo Luiz Souza; Nascimento,Andrews Marques do; Kalil,Iêda Carneiro; Lenz,Dominik; Bissoli,Nazaré Souza; Endringer,Denise Coutinho; Andrade,Tadeu Uggere de. |
| The aims of this study were to evaluate the chemical profile, vascular reactivity, and acute hypotensive effect (AHE) of the ethanolic extract of leaves of Alpinia purpurata (Vieill) K. Schum (EEAP). Its chemical profile was evaluated using HPLC-UV, ICP-OES, and colorimetric quantification of total flavonoids and polyphenols. The vascular reactivity of the extract was determined using the mesenteric bed isolated from WKY. AHE dose-response curves were obtained for both EEAP and inorganic material isolated from AP (IAP) in WKY and SHR animals. Cytotoxic and mutagenic safety levels were determined by the micronucleus test. Rutin-like flavonoids were quantified in the EEAP (1.8 ± 0.03%), and the total flavonoid and polyphenol ratios were 4.1 ± 1.8% and 5.1 ±... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Alpinia; Alpinia purpurata/phytochemistry; Alpinia purpurata/ethanolic extract/vascular reactivity; Alpinia purpurata/ethanolic extract/acute hypotensive effect; Flavonoids/quantification; Polyphenols/quantification. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000200309 |
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