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	Provedor de dados BABT (1) BJM (1) Autor Lin,Bin (2) Deng,Yongzhi (1) Guan,Xuefang (1) Qian,Lei (1) Tao,Yezheng (1) Wu,Lin (1) Xu,Qingxian (1) Ye,Qunhui (1) Yuan,Yu (1) Zheng,Yi (1) Mais... Palavra-chave BMP4 (1) Cholesterol (1) ERK1/2 signaling pathway (1) Fermented milk (1) Lactobacillus plantarum (1) Myocardial hypertrophy (1) Rat (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2019 (1) 2017 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última BMP4 Induces Cardiomyocyte Hypertrophy Through the Activation of ERK 1/2 Signaling Pathway in H9c2 Cells BABT Yuan,Yu; Tao,Yezheng; Deng,Yongzhi; Ye,Qunhui; Lin,Bin; Wu,Lin. Abstract Bone morphogenetic protein-4 (BMP4) is a member of the bone morphogenetic protein family which plays an important role in bone formation, inflammation and cardiac hypertrophy. The aim of this study was to investigate the underlying molecular mechanism that BMP4-induced cardiomyocyte hypertrophy. H9c2 cells were used to measure cell surface area and protein synthesis. Western blot was used to examine hypertrophic marker brain natriuretic peptide (BNP) protein expression and phosphorylation of ERK1/2. The results exhibited that cell surface area, protein synthesis and BNP protein expression were increased with BMP4 treatment. While PD98059 inhibited these effects of BMP4. In addition, BMP4 treatment increased phosphorylation of ERK1/2 in a time- and... Tipo: Info:eu-repo/semantics/article Palavras-chave: BMP4; Myocardial hypertrophy; ERK1/2 signaling pathway. Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132019000100315 Screening and characterization of lactic acid bacterial strains that produce fermented milk and reduce cholesterol levels BJM Guan,Xuefang; Xu,Qingxian; Zheng,Yi; Qian,Lei; Lin,Bin. ABSTRACT Objective To screen for and characterize lactic acid bacteria strains with the ability to produce fermented milk and reduce cholesterol levels. Methods The strains were isolated from traditional fermented milk in China. In vitro and in vivo evaluation of cholesterol-reduction were used to identify and verify strains of interest. Characteristics were analyzed using spectrophotometry and plate counting assays. Results The isolate HLX37 consistently produced fermented milk with strong cholesterol-reducing properties was identified as Lactobacillus plantarum (accession number: KR105940) and was thus selected for further study. The cholesterol reduction by strain HLX37 was 45.84%. The isolates were acid-tolerant at pH 2.5 and bile-tolerant at 0.5%... Tipo: Info:eu-repo/semantics/article Palavras-chave: Fermented milk; Lactobacillus plantarum; Cholesterol; Rat. Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822017000400730 Registros recuperados: 2 Primeira ... 1 ... Última

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