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	Provedor de dados Nature Precedings (1) Autor Haina Qin (1) Jianxing Song (1) Linlin Miao (1) Palavra-chave Chemistry (1) Earth & Environment (1) Evolutionary Biology (1) Molecular Cell Biology (1) Tipo do documento Manuscript (1) Ano 2012 (1) País United Kingdom (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última "Dark Mediators" of Proteins as Revealed by NMR in Water: Residue-selective Anion Bindings that are Masked by Pre-existing Buffer Nature Precedings Jianxing Song; Linlin Miao; Haina Qin. Ions are commonly believed to impose their effects on proteins by unspecific electrostatic screening. Here, by NMR we reveal that in water sulfate, chloride and thiocyanate are able to bind a well-folded WW domain at distinctive residues and affinities, which is surprisingly masked by the pre-existing buffer. Our study reveals that the specific anion binding is so ubiquitous and consequently no longer negligible in establishing "postreductionist framework" for protein biochemistry. Tipo: Manuscript Palavras-chave: Chemistry; Molecular Cell Biology; Earth & Environment; Evolutionary Biology. Ano: 2012 URL: http://precedings.nature.com/documents/6769/version/1 Registros recuperados: 1 Primeira ... 1 ... Última

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