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Reactome - a knowledgebase of human biological pathways Nature Precedings
Bijay Jassal; Esther E. Schmidt; Guanming Wu; Imre Vastrik; David Croft; Bernard de Bono; Gopal Gopinath; Marc Gillespie; Steven Jupe; Gavin O'Kelly; Lisa Matthews; Phani V. Garapati; Michael Caudy; Alexander Kanapin; Bruce May; Shahana Mahajan; Ewan Birney; Peter D'Eustachio; Lincoln Stein.
Reactome ("http://www.reactome.org":http://www.reactome.org) is an expert-authored, peer-reviewed knowledgebase of human reactions and pathways that functions as a data mining resource and electronic textbook. Its current release includes 2921 human proteins, 2871 reactions and 4167 literature citations. This curated dataset is integrated with a functional interaction network assembled computationally from non-curated sources of information including protein-protein interactions, gene co-expression, and gene ontology annotations, providing access. A new entity-level pathway viewer and improved search and data mining tools facilitate searching and visualizing pathway data and the analysis of user-supplied high-throughput data...
Tipo: Poster Palavras-chave: Chemistry; Genetics & Genomics; Immunology; Molecular Cell Biology; Bioinformatics.
Ano: 2009 URL: http://precedings.nature.com/documents/3200/version/1
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Reactome - a knowledgebase of human biological pathways Nature Precedings
Peter D'Eustachio; David Croft; Bernard de Bono; Gopal Gopinath; Marc Gillespie; Bijay Jassal; Lisa Matthews; Esther Schmidt; Imre Vastrik; Guanming Wu; Suzanna Lewis; Ewan Birney; Lincoln Stein.
Pathway curation is a powerful tool for systematically associating gene products with functions. Reactome (www.reactome.org) is a manually curated human pathway knowledgebase describing a wide range of biological processes in a computationally accessible manner. The core unit of the Reactome data model is the Reaction, whose instances form a network of biological interactions through entities that are consumed, produced, or act as catalysts. Entities are distinguished by their molecular identities and cellular locations. Set objects allow grouping of related entities. Curation is based on communication between expert authors and staff curators, facilitated by freely available data entry tools. Manually curated data are subjected to quality control and peer...
Tipo: Poster Palavras-chave: Molecular Cell Biology; Bioinformatics.
Ano: 2007 URL: http://precedings.nature.com/documents/1281/version/1
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