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	Provedor de dados Genet. Mol. Biol. (2) Autor Lizcano,Fernando (2) Vargas,Diana (2) Celis,Luis (1) Romero,Carolina (1) Palavra-chave Transcription (2) Co-activator (1) DNA binding proteins co-activator (1) EID1 (1) Gene expression (1) P300 (1) Telmisartan (1) Thyroid receptors (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2013 (1) 2008 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Modulation of thyroid hormone receptor transactivation by the early region 1A (E1A)-like inhibitor of differentiation 1 (EID1) Genet. Mol. Biol. Vargas,Diana; Celis,Luis; Romero,Carolina; Lizcano,Fernando. Transcriptional activation (TA) mediated by the effect of thyroid hormones on target genes requires co-activator proteins such as the early region 1A (E1A) associated 300 kDa binding protein (p300) and the cAMP response element binding protein (CREB) binding protein (CBP), known as the p300/CBP complex, which acetylate histones 3 and 4 to allow transcriptional machinery access to the target gene promoter. Little is known on the role of p300 in thyroid hormone receptor (TR) mediated TA but the E1A-like inhibitor of differentiation 1 (EID1), an inhibitor of p300 histone acetyltransferase (HAT), is a functional homolog of E1A and may inhibit myogenic differentiation factor D (MyoD) transcriptional activity and reduces muscle cell differentiation. We evaluated... Tipo: Info:eu-repo/semantics/article Palavras-chave: Co-activator; EID1; P300; Thyroid receptors; Transcription. Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572008000300003 Diverse coactivator recruitment through differential PPARγ nuclear receptor agonism Genet. Mol. Biol. Lizcano,Fernando; Vargas,Diana. The PPARγ nuclear receptor regulates the expression of genes involved in lipid and carbohydrate metabolism, and it has protective effects in some patients with type 2 diabetes. Nevertheless, the therapeutic value of the PPARγ nuclear receptor protein is limited due to the secondary effects of some PPARγ ligands. Because the downstream effects of PPARγ are determined by the binding of specific cofactors that are mediated by ligand-induced conformational changes, we evaluated the differential effects of various ligands on the binding of certain cofactors associated with PPARγ. The ligands used were rosiglitazone for treating type 2 diabetes and telmisartan for treating arterial hypertension. Functional, phenotypic, and molecular studies were conducted on... Tipo: Info:eu-repo/semantics/article Palavras-chave: DNA binding proteins co-activator; Gene expression; Transcription; Telmisartan. Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572013000100020 Registros recuperados: 2 Primeira ... 1 ... Última

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