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Intrauterine sexual differentiation: biosyntesis and action of sexual steroid hormones BABT
Santos,Amilton Cesar dos; Viana,Diego Carvalho; Oliveira,Gleidson Benevides de; Lobo,Luis Miguel; Assis-Neto,Antônio Chaves.
The objective of this review was to describe sexual differentiation events in mammals, relating them to biosynthesis of sexual steroid hormones and their mechanisms of action. Cholesterol is the precursor of sexual steroid hormone biosynthesis via action of several enzymes converting these hormones. Progestagens hormones serve as substrate for the production of androgens, which in turn serve as substrate for estrogen hormones. These hormones are responsible for sexual differentiation and reproductive cycles of mammals. Sexual differentiation process comprises determining the sexual chromosomes XX or XY + SRY and other genes linked to them, differentiation of gonads in testis or ovary, differentiation of internal and external male or female genital organs...
Tipo: Info:eu-repo/semantics/article Palavras-chave: P450 cytochrome; Sexual differentiation; Müllerian ducts; Wolff duct; Steroidogenesis.
Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132015000300395
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Development of Adrenal Glands from the Embryonic Phase to Puberty in Spix’s Yellow-toothed Cavies (Galea spixii, Wagler, 1831) BABT
Lobo,Luis Miguel; Santos,Amílton Cesar dos; Oliveira,Moacir Franco de; Assis-Neto,Antônio Chaves.
ABSTRACT Several authors have underscored the importance of establishing parameters in morphological development by gender comparison to establish clinical and pre-clinical assays through the use of experimental models. Current research compares the morphometry of right and left adrenal glands of males and females and describes differentiation of the cortex and medulla tissue during the embryonic, pre-puberty and puberty phases in Spix´s yellow-toothed cavies. Embryos aged 22 (22D), 25 (25D), 30 (30D), 40 (44D) and >50 (50D) days of gestation and neonates aged 15 (15DPN) (DPN= Days postnatal), 30 (30DPN) and 90 (90DPN) days after birth were analyzed. Comparisons included morphometric and histological analysis in all periods described. When compared the...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Adrenal córtex; Cavidae; Experimental model; Rodentia; Steroidogenesis.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132018000100444
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