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	Provedor de dados BJMBR (3) Autor Lv,Y. (3) Fu,L.C. (2) Du,L.Z. (1) Duan,T. (1) He,Q. (1) Liu,B. (1) Liu,X. (1) Lu,H. (1) Shen,H. (1) Shen,X.Q. (1) Wang,H.P. (1) Xu,J.H. (1) Zhang,L. (1) Zhong,Y. (1) Mais... Palavra-chave Bone marrow mesenchymal stem cell (1) Cardiomyocytes (1) Denervation (1) Differentiation (1) IUGR (1) Intramyocardial implantation (1) Kv1.5 (1) Muscle atrophy (1) Myogenin (1) PASMCs (1) Pulmonary hypertension (1) Satellite cells (1) Transfection (1) Transforming growth factor beta1 (1) Transplantation (1) Tyrosine phosphorylation (1) Mais... Tipo do documento Info:eu-repo/semantics/article (3) Ano 2017 (1) 2016 (2) País Brazil (3) Idioma Inglês (3)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 3 Primeira ... 1 ... Última Tyrosine phosphorylation of Kv1.5 is upregulated in intrauterine growth retardation rats with exaggerated pulmonary hypertension BJMBR Fu,L.C.; Lv,Y.; Zhong,Y.; He,Q.; Liu,X.; Du,L.Z.. Intrauterine growth retardation (IUGR) is associated with the development of adult-onset diseases, including pulmonary hypertension. However, the underlying mechanism of the early nutritional insult that results in pulmonary vascular dysfunction later in life is not fully understood. Here, we investigated the role of tyrosine phosphorylation of voltage-gated potassium channel 1.5 (Kv1.5) in this prenatal event that results in exaggerated adult vascular dysfunction. A rat model of chronic hypoxia (2 weeks of hypoxia at 12 weeks old) following IUGR was used to investigate the physiological and structural effect of intrauterine malnutrition on the pulmonary artery by evaluating pulmonary artery systolic pressure and vascular diameter in male rats. Kv1.5... Tipo: Info:eu-repo/semantics/article Palavras-chave: IUGR; Kv1.5; PASMCs; Pulmonary hypertension; Tyrosine phosphorylation. Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017001100604 Implantation of muscle satellite cells overexpressing myogenin improves denervated muscle atrophy in rats BJMBR Shen,H.; Lv,Y.; Shen,X.Q.; Xu,J.H.; Lu,H.; Fu,L.C.; Duan,T.. This study evaluated the effect of muscle satellite cells (MSCs) overexpressing myogenin (MyoG) on denervated muscle atrophy. Rat MSCs were isolated and transfected with the MyoG-EGFP plasmid vector GV143. MyoG-transfected MSCs (MTMs) were transplanted into rat gastrocnemius muscles at 1 week after surgical denervation. Controls included injections of untransfected MSCs or the vehicle only. Muscles were harvested and analyzed at 2, 4, and 24 weeks post-transplantation. Immunofluorescence confirmed MyoG overexpression in MTMs. The muscle wet weight ratio was significantly reduced at 2 weeks after MTM injection (67.17±6.79) compared with muscles injected with MSCs (58.83±5.31) or the vehicle (53.00±7.67; t=2.37, P=0.04 and t=3.39, P=0.007, respectively). The... Tipo: Info:eu-repo/semantics/article Palavras-chave: Denervation; Muscle atrophy; Satellite cells; Myogenin; Transplantation; Transfection. Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016000200609 Intramyocardial implantation of differentiated rat bone marrow mesenchymal stem cells enhanced by TGF-β1 improves cardiac function in heart failure rats BJMBR Lv,Y.; Liu,B.; Wang,H.P.; Zhang,L.. The present study tested the hypotheses that i) transforming growth factor beta 1 (TGF-β1) enhances differentiation of rat bone marrow mesenchymal stem cells (MSCs) towards the cardiomyogenic phenotype and ii) intramyocardial implantation of the TGF-β1-treated MSCs improves cardiac function in heart failure rats. MSCs were treated with different concentrations of TGF-β1 for 72 h, and then morphological characteristics, surface antigens and mRNA expression of several transcription factors were assessed. Intramyocardial implantation of these TGF-β1-treated MSCs to infarcted heart was also investigated. MSCs were initially spindle-shaped with irregular processes. On day 28 after TGF-β1 treatment, MSCs showed fusiform shape, orientating parallel with one... Tipo: Info:eu-repo/semantics/article Palavras-chave: Bone marrow mesenchymal stem cell; Transforming growth factor beta1; Cardiomyocytes; Differentiation; Intramyocardial implantation. Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016000600603 Registros recuperados: 3 Primeira ... 1 ... Última

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