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| Lyra,Andre C.; Fan,Xiaofeng; Di Bisceglie,Adrian M.. |
| CD81 is a surface-associated protein expressed in the membranes of mammalian cells. It has been suggested that CD81 interacts with hepatitis C virus E2 protein, and thus might facilitate the entry of HCV into hepatocytes. The envelope-binding site appears to involve amino acids (aa) 480-493 and 544-551 within the E2 glycoprotein. Little is known about the quasispecies genetic diversity of these two regions. We studied four patients who underwent transplantation for HCV-related cirrhosis and who developed recurrent hepatitis C. We evaluated HCV quasispecies diversity in serum samples obtained at the time of transplantation and at several time points thereafter. Quasispecies diversity was assessed by cloning and sequencing of viral isolates, with computer... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Hepatitis C virus; CD81; Diversity. |
| Ano: 2004 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702004000200002 |
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| Lyra,Andre C.; Santana,Genoile; Santana,Nelma; Silvany-Neto,Anibal; Magalhães,Emilia; Pereira,Eduardo M.; Mascarenhas,Ramiro; Lyra,Marcos C.; Veiga,Andrea; Ferreira,Karina; Zaterka,Schilioma; Lyra,Luiz G.. |
| Helicobacter pylori plays an important role in the etiology of peptic ulcer disease. Its prevalence appears to be higher in developing countries. We evaluated the seroprevalence of H. pylori and risk factors associated with infection in voluntary blood donors who attended the main blood center of the city of Salvador, Brazil. The subjects responded to an epidemiological questionnaire, with information about sex, age, race, lifestyle, social-economic level indicators, and residence and hygiene conditions. Anti-H. pylori antibody was determined by ELISA (Cobas Core, Roche). Three hundred and seven subjects were included in the study. Anti-H. pylori antibody results were indeterminate in 33 individuals (10.8%), who were excluded from analysis. Among the... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: H. pylori; Seroprevalence; Risk factors; Brazil. |
| Ano: 2003 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000500009 |
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