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Bioinformatic prediction of polymerase elements in the rotavirus VP1 protein Biol. Res.
VÁSQUEZ-DEL CARPIÓ,RODRIGO; MORALES,JAIME L; BARRO,MARIO; RICARDO,ALBA; SPENCER,EUGENIO.
Rotaviruses are the major cause of acute gastroenteritis in infants world-wide. The genome consists of eleven double stranded RNA segments. The major segment encodes the structural protein VP1, the viral RNA-dependent RNA polymerase (RdRp), which is a minor component of the viral inner core. This study is a detailed bioinformatic assessment of the VP1 sequence. Using various methods we have identified canonical motifs within the VP1 sequence which correspond to motifs previously identified within RdRps of other positive strand, double-strand RNA viruses. The study also predicts an overall structural conservation in the middle region that may correspond to the palm subdomain and part of the fingers and thumb subdomains, which comprise the polymerase core of...
Tipo: Journal article Palavras-chave: Rotavirus; Genome replication; RNA polymerase; Bioinformatic analysis.
Ano: 2006 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602006000500008
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