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	Provedor de dados BJMBR (2) Autor Ma,Lei (2) An,Rong-Zhen (1) Chen,Yongjun (1) Guan,Xiu-Hao (1) Han,Rui (1) Shu,Chun-Mei (1) Wang,Shuangyi (1) Xue,Hai-Bo (1) Zhang,Jun-Hua (1) Zhang,Yu-Jie (1) Mais... Palavra-chave Apoptosis (1) Benzyl isothiocyanate (1) MMP-9 (1) Migration inhibitory factor (1) Oral squamous cell carcinoma (1) PUMA (1) S100A4 (1) Vitiligo vulgaris (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2019 (1) 2013 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Relationship of macrophage migration inhibitory factor levels in PBMCs, lesional skin and serum with disease severity and activity in vitiligo vulgaris BJMBR Ma,Lei; Xue,Hai-Bo; Guan,Xiu-Hao; Shu,Chun-Mei; Zhang,Yu-Jie; Zhang,Jun-Hua; An,Rong-Zhen. Melanocyte loss in vitiligo vulgaris is believed to be an autoimmune process. Macrophage migration inhibitory factor (MIF) is involved in many autoimmune skin diseases. We determined the possible role of MIF in the pathogenesis of vitiligo vulgaris, and describe the relationship between MIF expressions and disease severity and activity. Serum MIF concentrations and mRNA levels in PBMCs were measured in 44 vitiligo vulgaris patients and 32 normal controls, using ELISA and real-time RT-PCR. Skin biopsies from 15 patients and 6 controls were analyzed by real-time RT-PCR. Values are reported as median (25th-75th percentile). Serum MIF concentrations were significantly increased in patients [35.81 (10.98-43.66) ng/mL] compared to controls [7.69 (6.01-9.03)... Tipo: Info:eu-repo/semantics/article Palavras-chave: Migration inhibitory factor; Vitiligo vulgaris. Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013000500460 Benzyl isothiocyanate inhibits invasion and induces apoptosis via reducing S100A4 expression and increases PUMA expression in oral squamous cell carcinoma cells BJMBR Ma,Lei; Chen,Yongjun; Han,Rui; Wang,Shuangyi. Benzyl isothiocyanate (BITC) has been shown to inhibit invasion and induce apoptosis of various types of cancer. However, its role on human oral squamous cell carcinoma (OSCC) cells is still not well elucidated. In the present study, we investigated the effect of BITC on apoptosis and invasion of SCC9 cells, and its underlying mechanisms in vitro and in vivo. SCC9 cells were exposed to BITC (5 and 25 μM) for 24 and 48 h. Cell growth, apoptosis, invasion, and migration were detected in vitro by MTT, FITC-conjugated annexin V/propidium iodide staining followed by flow cytometry, Matrigel-coated semi-permeable modified Boyden, and wound-healing assay. S100A4, PUMA, and MMP-9 expressions were detected to investigate its mechanisms. Xenotransplantation... Tipo: Info:eu-repo/semantics/article Palavras-chave: Oral squamous cell carcinoma; Benzyl isothiocyanate; Apoptosis; S100A4; MMP-9; PUMA. Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2019000400605 Registros recuperados: 2 Primeira ... 1 ... Última

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