|
|
| Chen,X.Q.; Wang,F.; Zheng,Y.L.; Fan,Q.X.; Yue,D.L.; Ma,Z.J.. |
| Esophageal cancer (EC) is a common malignancy worldwide. The X-ray repair cross-complementing 1 gene (XRCC1) is one of the most important candidate genes for influencing susceptibility to EC. This study aimed to investigate the effect of XRCC1 genetic variants on susceptibility to EC. A total of 383 EC patients (males: 239, females: 144, mean age: 56.62) and 387 cancer-free controls (males: 251, females: 136, mean age: 58.23) were enrolled in this study. The c.910A>G genetic variant of theXRCC1 gene was determined by polymerase chain reaction-restriction fragment length polymorphism and DNA sequencing methods. The allele and genotype frequencies indicated statistical differences between EC patients and cancer-free controls. The c.910A>G genetic... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Esophageal cancer; XRCC1 gene; Genetic variant; Molecular marker; Susceptibility. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013001201028 |
| |
