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| Machado,Elizabeth S.; Lambert,John S.; Afonso,Adriana O.; Cunha,Silvia M.; Oliveira,Ricardo H.; Tanuri,Amilcar; Sill,Anne M.; Soares,Marcelo A.. |
| Although mother-to-child HIV transmission prevention has slowed down pediatric HIV infection in developed countries, large numbers of infants still become infected in developing nations. Data on pediatric HIV infection is however largely scarce. In this study, we have overviewed clinical, laboratory and genotypic data from a large cohort of HIV-infected infants regularly followed at two pediatric HIV outpatient clinics in Rio de Janeiro, Brazil. Children on antiretroviral therapy, as well as drug-naïve, newly diagnosed infants were analyzed. Prevalence of drug resistance mutations, as well as immunological and virological responses to therapy were evaluated. Additionally, HIV-1 subtype frequencies and their distribution over the course of the epidemic were... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: HIV-1; Pediatric; Drug resistance; Clinical; Genotyping; Subtype. |
| Ano: 2004 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652004000400008 |
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| Hofer,Cristina B.; Oliveira,Ricardo Hugo; Machado,Elizabeth S.; Pala,Alessandra; Evangelista,Lúcia; Fernandes,Iraina; Abreu,Thalita F.. |
| There are only scarce data on HIV progression in vertically infected children in developing countries. The aim of this study is to describe factors from neonatal period associated with long term non-progression (LTNP), in a Brazilian cohort. A cohort study, with data systematically collected from the "Peixe" Cohort (cohort study of children conducted at the main HIV Pediatric Center in Rio de Janeiro, from 1996 to 2005). The study included children who were vertically infected and started follow up at 5 years of age or younger. LTNP, defined as not reaching category C or severe immunosuppression before 5 years of age. Neonatal and demographic factors were studied. Variables with p-value<0.15 were included in a logistic regression model. 213 patients... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: HIV; Antiretroviral therapy; Long term non-progressors; Children; Brazil. |
| Ano: 2009 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000400007 |
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| Lundberg,Per; Andersson,Rune; Machado,Elizabeth S.; Costa,Tomaz Pinheiro da; Hofer,Cristina Barroso. |
| ABSTRACT Background: Perinatally HIV-infected children are surviving into adulthood, and getting pregnant. There is a scarcity of information on health and pregnancy outcomes in these women. Aim: To evaluate characteristics related to HIV disease and pregnancy outcomes in perinatally infected women, and to compare these women with a group of youth with behaviorally acquired HIV-infection, at a reference hospital in Rio de Janeiro, Brazil. Methods: A cohort study. Epidemiological, clinical, and laboratory data were compared between perinatally (PHIV) and behaviorally HIV-infected (BHIV) pregnant youth with the primary aim to study pregnancy outcomes in the PHIV group and compare with outcomes to BHIV group. Results: Thirty-two pregnancies occurred in... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Perinatal HIV; Pregnancy; Mother-to-child transmission; Combined antiretroviral treatment. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000500412 |
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| Nogueira,Susie Andries; Guedes,Ana Lúcia; Machado,Elizabeth S.; Matos,Juliana A.; Costa,Tomás P.; Cortes,Ely M.; Lambert,John S.. |
| This report describes a case of Toxoplasma encephalitis during pregnancy of an HIV infected woman who was severely immunosuppressed (CD4: 17 cells/mm3), had a high viral load (RNA PCR:230,000 copies/ml), was treated with sulfadiazine, pyrimethamine and folinic acid for toxoplasmosis and was being treated with highly potent antiretroviral drugs (AZT, 3TC and nelfinavir) for HIV infection. The newborn was born through an elective C-section, received six weeks of AZT according to the 076 protocol and was clinically normal at birth. Subsequently he had two RNA PCR negatives for HIV, seroreverted and had no clinical or laboratory evidence of congenital toxoplasmosis. Despite the concerns of the use of these combined therapies on the foetus during pregnancy,... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Toxoplasma encephalitis; Pregnancy; HIV/AIDS; Prevention of vertical transmission. |
| Ano: 2002 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702002000400008 |
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