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Mirtazapine versus fluoxetine in the treatment of panic disorder BJMBR
Ribeiro,L.; Busnello,J.V.; Kauer-Sant'Anna,M.; Madruga,M.; Quevedo,J.; Busnello,E.A.D.; Kapczinski,F..
Mirtazapine is an antidepressant whose side effect profile differs from that of first-line agents (selective serotonin reuptake inhibitors) used in the treatment of panic disorder. The present study compared the effect of mirtazapine and fluoxetine in the treatment of panic disorder in a double-blind, randomized, flexible-dose trial conducted with outpatients. After a 1-week single-blind placebo run-in, 27 patients entered an 8-week double-blind phase in which they were randomly assigned to treatment with either mirtazapine or fluoxetine. Both groups improved significantly in all but one efficacy measure (P<=0.01). ANOVA showed no significant differences between the two treatment groups in number of panic attacks, Hamilton Anxiety Scale or Sheehan...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Mirtazapine; Fluoxetine; Panic disorder; Treatment; Randomized trial.
Ano: 2001 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001001000010
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Increased training prevents the impairing effect of intra-amygdala infusion of the non-NMDA receptor antagonist CNQX on inhibitory avoidance expression BJMBR
Roesler,R.; Quevedo,J.; Rodrigues,C.; Madruga,M.; Vianna,M.R.M.; Ferreira,M.B.C..
Intra-amygdala infusion of the non-N-methyl-D-aspartate (NMDA) receptor antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) prior to testing impairs inhibitory avoidance retention test performance. Increased training attenuates the impairing effects of amygdala lesions and intra-amygdala infusions of CNQX. The objective of the present study was to determine the effects of additional training on the impairing effects of intra-amygdala CNQX on expression of the inhibitory avoidance task. Adult female Wistar rats bilaterally implanted with cannulae into the border between the central and the basolateral nuclei of the amygdala were submitted to a single session or to three training sessions (0.2 mA, 24-h interval between sessions) in a step-down inhibitory...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Amygdala; Non-NMDA receptor; Long-term potentiation; Inhibitory avoidance; Memory; Fear.
Ano: 1999 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000300016
Registros recuperados: 2
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