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	Provedor de dados BJPS (1) Autor Islambulchilar,Ziba (1) Jannatabadi,Ensieh (1) Lotfipour,Farzaneh (1) Majidpour,Fatemeh (1) Valizadeh,Hadi (1) Zakeri-Milani,Parvin (1) Mais... Palavra-chave Clarithromycin/nanoparticles/ permeability (1) Intestinal permeability (1) Single-Pass Intestinal Perfusion (1) Tipo do documento Info:eu-repo/semantics/article (1) Ano 2014 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última A study on enhanced intestinal permeability of clarithromycin nanoparticles BJPS Zakeri-Milani,Parvin; Islambulchilar,Ziba; Majidpour,Fatemeh; Jannatabadi,Ensieh; Lotfipour,Farzaneh; Valizadeh,Hadi. The main objective of the present study was to determine the permeability of clarithromycin (CLA)-PLGA nanoparticles using single-pass intestinal perfusion technique in rats. Clarithromycin nanoparticles were prepared by nano-precipitation according to the modified quasi emulsion solvent diffusion technique and evaluated for their physicochemical characteristics. Permeability coefficients (Peff) in anaesthetized rats were determined at 3 different concentrations. Drug solution or suspensions in PBS was perfused through a cannulated jejunal segment and samples were taken from outlet tubing at different time points up to 90 min. Microbiological assay of CLA and phenol red in the samples were analyzed using an agar well diffusion procedure and HPLC method... Tipo: Info:eu-repo/semantics/article Palavras-chave: Clarithromycin/nanoparticles/ permeability; Single-Pass Intestinal Perfusion; Intestinal permeability. Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000100012 Registros recuperados: 1 Primeira ... 1 ... Última

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