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	Provedor de dados BJPS (2) Autor Mandal,Snigdha Das (2) Mandal,Surjyanarayan (2) Chuttani,Krishna (1) Patel,Jayvadan (1) Subudhi,Bharat Bhushan (1) Palavra-chave Box-Behnken design (1) Curcumin/neuroprotective effect (1) Drugs/design (1) Ibuprofen/brain-targeting (1) Ibuprofen/intranasal administration (1) Ibuprofen/mucoadhesion (1) Male mice C57BL/6 (1) Mucoadhesive microemulsion gel (1) Neurodegradation (1) Parkinson's disease/treatment (1) Response surface methodology (RSM) (1) Sodium hyaluronate (1) Transmission electron microscopy (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2017 (1) 2015 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Intranasal mucoadhesivemicroemulsion for neuroprotective effect of curcuminin mptp induced Parkinson model BJPS Mandal,Snigdha Das; Mandal,Surjyanarayan; Patel,Jayvadan. ABSTRACT This study was to investigate the neuroprotective effect of curcumin against inflammation-mediated dopaminergic neurodegeneration in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mice model of Parkinson's disease (PD). Curcumin loaded sodium hyaluronate based mucoadhesive microemulsion (CMME) was developed by using Box Behnken design of Response surface method (RSM) and was characterized. Male C57BL/6 mice were first treated with four intraperitoneal injections of MPTP (20 mg/kg of body weight) at 2 h intervals followed CMME intranasal administration for 14 days at 2.86 mg of curcumin/kg of body weight per once a day. Optimal CMME containing 3% Capmul MCM as oil phase, 37 % of Accenon CC and Transcutol HP at 2.5:1 ratio and 0.5% sodium... Tipo: Info:eu-repo/semantics/article Palavras-chave: Curcumin/neuroprotective effect; Response surface methodology (RSM); Box-Behnken design; Sodium hyaluronate; Neurodegradation; Parkinson's disease/treatment; Male mice C57BL/6. Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000200621 Mucoadhesive microemulsion of ibuprofen: design and evaluation for brain targeting efficiency through intranasal route BJPS Mandal,Surjyanarayan; Mandal,Snigdha Das; Chuttani,Krishna; Subudhi,Bharat Bhushan. This study aimed at designing mucoadhesive microemulsion gel to enhance the brain uptake of Ibuprofen through intranasal route. Ibuprofen loaded mucoadhesive microemulsion (MMEI) was developed by incorporating polycarbophil as mucoadhesive polymer into Capmul MCM based optimal microemulsion (MEI) and was subjected to characterization, stability, mucoadhesion and naso-ciliotoxicity study. Brain uptake of ibuprofen via nasal route was studied by performing biodistribution study in Swiss albino rats. MEI was found to be transparent, stable and non ciliotoxic with 66.29 ± 4.15 nm, -20.9 ± 3.98 mV and 98.66 ± 1.01% as average globule size, zeta potential and drug content respectively. Transmission Electron Microscopy (TEM) study revealed the narrow globule size... Tipo: Info:eu-repo/semantics/article Palavras-chave: Ibuprofen/brain-targeting; Ibuprofen/intranasal administration; Ibuprofen/mucoadhesion; Mucoadhesive microemulsion gel; Drugs/design; Transmission electron microscopy. Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502015000300721 Registros recuperados: 2 Primeira ... 1 ... Última

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