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	Provedor de dados 47 (2) Autor Manucha,Walter (2) Benardón,María Eugenia (1) Cacciamani,Valeria (1) García,Isabel Mercedes (1) Mazzei,Luciana (1) Palavra-chave Angiotensin II (1) Apoptosis (1) Interstitial fibrosis (1) Kidney development (1) Nitric oxide (1) Obstructive nephropathy (1) Oxidative stress (1) Statins (1) Unilateral ureteral obstruction (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2010 (1) 2007 (1) País Argentina (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Biochemical-molecular markers in unilateral ureteral obstruction 47 Manucha,Walter. Congenital obstructive nephropathy is the primary cause of end-stagerenal disease in children. Rapid diagnosis and initiation of the treatment are vital to preserve function and/or to slow down renal injury. Obstr uctive uropathy effects-decline in the plasmatic renal flow and glomerular filtrationrate, interstitial infiltrate of leukocytes, significant decrease of the urine concentration, loss of the capacity to concentrate urine as well as fibrosis and apoptosisare a consequence of a variety of factors that work in complex ways and are still not fully understood. Mediators as angiotensin II, transforming growth factor-b (TGF-b) and nitric oxide (NO) have been implicated in congenital obstructive nephropathy. The renin-angiotensin system is regulated in... Tipo: Info:eu-repo/semantics/article Palavras-chave: Unilateral ureteral obstruction; Interstitial fibrosis; Nitric oxide; Angiotensin II; Oxidative stress. Ano: 2007 URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0327-95452007000100001 WT-1 mRNA expression is modulated by nitric oxide availability and Hsp70 interaction after neonatal unilateral ureteral obstruction 47 Mazzei,Luciana; García,Isabel Mercedes; Cacciamani,Valeria; Benardón,María Eugenia; Manucha,Walter. Wilms tumor gene 1 (wt-1), a key regulator of mesenchymal-epithelial transformation, is downregulated during congenital obstructive nephropathy, leading to apoptosis. There is a functional interaction between WT-1 and inducible nitric oxide synthase (iNOS). In this regard, we reported that after neonatal unilateral ureteral obstruction, rosuvastatin prevents apoptosis through an increase in nitric oxide bioavailability, which in turn is linked to higher Hsp70 expression. Hence, the goal of this study was to determine whether a nitric oxide/Hsp70 interaction is involved in changes in WT-1 mRNA expression after ureteral obstruction. Neonatal rats submitted to experimental ureteral obstruction were treated with either vehicle or rosuvastatin for 14 days.... Tipo: Info:eu-repo/semantics/article Palavras-chave: Obstructive nephropathy; Apoptosis; Statins; Kidney development. Ano: 2010 URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0327-95452010000300004 Registros recuperados: 2 Primeira ... 1 ... Última

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