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Prostate-specific membrane antigen can promote in vivo osseous metastasis of prostate cancer cells in mice BJMBR
Zhao,Liang-Yun; Mao,Xiao-Peng; Chao,Kai-Yuan; Guo,Sheng-Jie; Qiu,Shao-Peng.
Reports remain insufficient on whether and how prostate-specific membrane antigen (PSMA) can influence in vivo osseous metastasis of prostate cancer (PCa). In the present study, the authors induced stable expression of PSMA in mouse PCa cell line RM-1. In vivo osseous metastasis was induced in 37 6-week-old female C57BL/6 mice weighing 22.45 ± 0.456 g. RM-1 cells were actively injected into the femoral bone cavity, leading to bilateral dissymmetry of bone density in the femoral bone. Tumor cells were also detected in bone tissue by pathological examination. The impact on bone density was demonstrated by the significant difference between animals injected with RM-PSMA cells (0.0738 ± 0.0185 g/cm²) and animals injected with RM-empty plasmid cells (0.0895 ±...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Prostate carcinoma; Prostate-specific membrane antigen; In vitro; Osseous metastasis.
Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000800008
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