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	Provedor de dados Nature Precedings (1) Autor Anne-Sophie Frojmark (1) Jens Schuster (1) Jitendra Badhai (1) Joakim Klar (1) Maria Thuveson (1) Niklas Dahl (1) Mais... Palavra-chave Molecular Cell Biology (1) Tipo do documento Manuscript (1) Ano 2009 (1) País United Kingdom (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Cooperative effect of ribosomal protein s19 and Pim-1 kinase on murine c-Myc expression and myeloid/erythroid cellularity Nature Precedings Anne-Sophie Frojmark; Jitendra Badhai; Joakim Klar; Maria Thuveson; Jens Schuster; Niklas Dahl. Diamond Blackfan anemia (DBA) is a bone marrow failure syndrome associated with heterozygous mutations in the ribosomal protein S19 (RPS19) gene in a subgroup of patients. One of the interacting partners with RPS19 is the oncoprotein PIM-1 kinase. We intercrossed Rps19+/- and Pim-1-/- mice strains to study the effect from the disruption of both genes. The double mutant (Rps19+/-Pim-1-/-) mice display normal growth with increased peripheral white- and red blood cell counts when compared to the w.t. mice (Rps19+/+Pim-1+/+). Molecular analysis of bone marrow cells in Rps19+/-Pim-1-/- mice revealed up-regulated levels of c-Myc and the anti-apoptotic factors Bcl2, BclXL and Mcl-1. This is associated with a reduction of the apoptotic factors Bak and Caspase 3 as... Tipo: Manuscript Palavras-chave: Molecular Cell Biology. Ano: 2009 URL: http://precedings.nature.com/documents/2882/version/1 Registros recuperados: 1 Primeira ... 1 ... Última

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