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Technetium-99m ceftizoxime kit preparation BABT
Diniz,Simone Odília Fernandes; Siqueira,Cristiano Ferrari; Nelson,David Lee; Martin-Comin,Josep; Cardoso,Valbert Nascimento.
The aim of this work was to prepare a kit of 99mTc-ceftizoxime (99mTc-CFT), with stability and biological activity preserved, able to identify a septic focus (E. coli) in the experimental infection model in rats. The preparation of the CFT kit involved the use of lyophilized solutions containing the antibiotic ceftizoxime and the sodium dithionite reducing agent (6.0 mg/mL). After lyophilization, the kit was reconstituted with 1.0 mL of sodium 99mTc-pertechnetate solution (Na99mTcO4-) with an activity of 370 MBq. The solution was boiled for 10 min and filtered through a cellulose ester filter. The labeling efficiency was on the order of 92%, remaining stable for six hours and the kit remained stable for two months. The biological activity of the 99mTc-CFT...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Tc-99m Ceftizoxime; Infection; Gamma scintigraphy.
Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132005000700014
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Factors associated with the non detection of the sentinel node in breast cancer BABT
Guirao,Sara; Benítez Segura,Ana; Bajén,Maria Tereza; Brulles,Ynonet Ricart; Salvado,Jaume Mora; Vilardell,Ana Domenech; Rodriguez Gassen,Alba; Engronyat,Manel Roca; Puchal Añe,Rafael; Martin-Comin,Josep.
The aim of the work was to analyse the potential influence of different factors on the surgical detection of sentinel lymph node in breast cancer. The procedure has been performed in 704 patients. In 43 out of the 704 cases, the SN was not detected, 24 were palpable and 19 had no palpable tumors. Lymphoscitigraphy was done in 2 h p.i. of 37-55 MBq of 99mTc-nanocolloid. The day before surgery in palpable tumours and 4 h previous to surgery in non-palpable tumours, surgical detection was performed using a gammaprobe. The following factors were analysed: patient age, tumour size, breast quadrant tumour localization, scintigraphic visualizatio,n and the palpation of the tumour. Results: Patient age was significantly (p<0.001) higher in the patients in whom...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Sentinel node; Breast cancer.
Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132005000700026
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