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| Padua,I.R.M.; Ribeiro,A.P.; Padua,P.P.M.; Guimarães,P.J.; Silva,M.L.; Piso,D.Y.T.; Martins,B.; Aldrovani,M.; Semolin,L.M.S.; Camacho,A.A.; Laus,J.L.. |
| ABSTRACT The aim of this study was to evaluate changes in intraocular pressure (IOP), pupil size (PS), blood pressure (BP), heart rate (HR), and ECG variables (Pms wave PmV, PR interval, QRS complex, RMV wave and QT intervals) over time during the instillation of 0.5% timolol, 0.5% levobunolol and 0.5% apraclonidine in clinically normal dogs. Ten adult beagles were used. Baseline values were measured at 8a.m., 2p.m. and 8p.m., for three consecutive days. A waiting period of 10 days between the administrations of each drug was established. For 15 consecutive days, the drug being tested was instilled in one eye of each dog twice a day (7a.m. and 7p.m.). The parameters were evaluated at the aforementioned times on days 3, 6, 9, 12 and 15. Data were... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Dog; Timolol maleate; Levobunolol; Apraclonidine; Intraocular pressure; Pupil size; Heart rate; Blood pressure. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352016000300641 |
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