|
|
| Benedetto,Raquel; Massicano,Adriana Vidal Fernandes; Silva,Jefferson Jesus; Boas,Cristian Antonio Wieczorek Villas; Mengatti,Jair; Araújo,Elaine Bortoleti de. |
| ABSTRACT Scientific innovations in diagnostic methods are important drivers of cancer control and prevention. Noninvasive imaging of the epidermal growth factor receptor (EGFR) in head-and-neck squamous, cell carcinoma and colorectal cancer could be valuable to select patients for EGFR-targeted therapy, as well as to monitor the efficacy and occurrence of resistance to immunotherapy. In order to develop the first Brazilian radioimmunoconjugate for diagnosis, Cetuximab has been conjugated to p-SCN-Bn-DTPA chelator and radiolabeled with Indium-111. The conjugation methodology was optimized using different mAb:DTPA molar ratios, time was then reduced for immunoconjugate preparation, besides the protein recovery’ percentage increased after purification (m =... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Radioimmunoconjugate/development; Head and neck cancer/diagnosis; Tumors diagnosis; Cetuximab; SPECT; 111In. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000400624 |
| |
