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| Rabelo,M.; Souza,E.P.; Soares,P.M.G.; Miranda,A.V.; Matos,F.J.A.; Criddle,D.N.. |
| We have investigated the antinociceptive effects of the essential oil of Ocimum gratissimum L. (Labiatae) (EOOG) in two classical models of pain in male Swiss mice (25-35 g), the writhing test and the formalin test. At doses of 30, 100 and 300 mg/kg (po), EOOG produced a dose-dependent inhibition (from 58.3 ± 4.4 to 40.7 ± 6.3, 36.4 ± 3.6 and 24.6 ± 3.6, respectively; N = 8-10, P<0.05) of acetic acid-induced writhing, causing up to a ~60% inhibition at the highest dose used, comparable to that obtained with indomethacin (10 mg/kg, po). At the same doses, EOOG predominantly inhibited the late (inflammatory) phase of the formalin-induced pain response (from 59.3 ± 8.3 to 40.4 ± 4.8, 23.2 ± 2.8 and 25.3 ± 5.5, respectively; N = 6, P<0.05), with a... |
| Tipo: Info:eu-repo/semantics/other |
Palavras-chave: Ocimum gratissimum L.; Labiatae; Essential oil; Antinociception. |
| Ano: 2003 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000400016 |
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| Botelho,M.A.; Nogueira,N.A.P.; Bastos,G.M.; Fonseca,S.G.C.; Lemos,T.L.G.; Matos,F.J.A.; Montenegro,D.; Heukelbach,J.; Rao,V.S.; Brito,G.A.C.. |
| Dental caries and periodontal disease are associated with oral pathogens. Several plant derivatives have been evaluated with respect to their antimicrobial effects against such pathogenic microorganisms. Lippia sidoides Cham (Verbenaceae), popularly known as "Alecrim-pimenta" is a typical shrub commonly found in the Northeast of Brazil. Many plant species belonging to the genus Lippia yield very fragrant essential oils of potential economic value which are used by the industry for the commercial production of perfumes, creams, lotions, and deodorants. Since the leaves of L. sidoides are also extensively used in popular medicine for the treatment of skin wounds and cuts, the objective of the present study was to evaluate the composition and antimicrobial... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Lippia sidoides; Essential oil; Antimicrobial activity; Oral pathogens. |
| Ano: 2007 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000300010 |
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