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| Matthias Samwald. |
| Key assertions are extracted from “conclusions” sections of PubMed abstracts and
converted into Semantic Web / Linked Data format. The results are made accessible via
files, a SPARQL endpoint, and a faceted search interface. Conclusion sections are
identified as valuable resources for machine-augmented key assertion identification and
integration in the biomedical domain. Results are discussed and opportunities for future
work and cooperation are highlighted.
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| Tipo: Manuscript |
Palavras-chave: Bioinformatics. |
| Ano: 2009 |
URL: http://precedings.nature.com/documents/3775/version/1 |
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| Matthias Samwald. |
| Dystroglycan is part of a large complex of proteins, the dystrophin-glycoprotein complex, which has been implicated in the pathogenesis of muscular dystrophies for a long time. Besides muscular degeneration many patients manifest symptoms of neurological and cognitive dysfunction. Newer findings suggest that dystroglycan is implicated in brain development, synapse formation and plasticity, nerve-glia interactions and maintenance of the blood-brain barrier.
Most research so far has focused on the functions of dystroglycan in muscle and neuromuscular junctions, while its role in the brain and interneuronal synapses has been largely neglected. 
This review will give an overview of the biochemistry of dystroglycan, its... |
| Tipo: Manuscript |
Palavras-chave: Neuroscience. |
| Ano: 2007 |
URL: http://precedings.nature.com/documents/196/version/1 |
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