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	Provedor de dados BJMBR (2) Autor Faccioli,L.H. (2) Medeiros,A.I. (2) Bonato,V.L.D. (1) Fedatto,P.F. (1) Fonseca,D.M. da (1) Franco,L.H. (1) Gembre,A.F. (1) Paula,M. Oliveira e (1) Ramos,S.G. (1) Silva,C.L. (1) Sá-Nunes,A. (1) Sérgio,C.A. (1) Wowk,P.F. (1) Mais... Palavra-chave Anti-IL-5 monoclonal antibody (1) Eosinophils (1) Histoplasma capsulatum (1) Inflammation (1) Interleukin-5 (1) Leukotrienes (1) Prime-boost immunization (1) Tuberculosis (1) Mais... Tipo do documento Info:eu-repo/semantics/other (2) Ano 2010 (1) 2004 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Leukotrienes are not essential for the efficacy of a heterologous vaccine against Mycobacterium tuberculosis infection BJMBR Franco,L.H.; Paula,M. Oliveira e; Wowk,P.F.; Fonseca,D.M. da; Sérgio,C.A.; Fedatto,P.F.; Gembre,A.F.; Ramos,S.G.; Silva,C.L.; Medeiros,A.I.; Faccioli,L.H.; Bonato,V.L.D.. Leukotrienes are reported to be potent proinflammatory mediators that play a role in the development of several inflammatory diseases such as asthma, rheumatoid arthritis and periodontal disease. Leukotrienes have also been associated with protection against infectious diseases. However, the role of leukotrienes in Mycobacterium tuberculosis infection is not understood. To answer this question, we studied the role of leukotrienes in the protective immune response conferred by prime-boost heterologous immunization against tuberculosis. We immunized BALB/c mice (4-11/group) with subcutaneous BCG vaccine (1 x 10(5) M. bovis BCG) (prime) followed by intramuscular DNA-HSP65 vaccine (100 µg) (boost). During the 30 days following the challenge, the animals were... Tipo: Info:eu-repo/semantics/other Palavras-chave: Tuberculosis; Prime-boost immunization; Leukotrienes. Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010000700006 Interleukin-5 mediates peritoneal eosinophilia induced by the F1 cell wall fraction of Histoplasma capsulatum BJMBR Sá-Nunes,A.; Medeiros,A.I.; Faccioli,L.H.. An alkali-insoluble fraction 1 (F1), which contains mainly ß-glucan isolated from the cell wall of Histoplasma capsulatum, induces eosinophil recruitment into the peritoneal cavity of mice. The present study was carried out to determine the participation of interleukin-5 (IL-5) in this process. Inbred C57BL/6 male mice weighing 15-20 g were treated ip with 100 µg of anti-IL-5 monoclonal antibody (TRFK-5, N = 7) or an isotype-matched antibody (N = 7), followed by 300 µg F1 in 1 ml PBS ip 24 h later. Controls (N = 5) received only 1 ml PBS. Two days later, cells from the peritoneal cavity were harvested by injection of 3 ml PBS and total cell counts were determined using diluting fluid in a Neubauer chamber. Differential counts were performed using... Tipo: Info:eu-repo/semantics/other Palavras-chave: Eosinophils; Histoplasma capsulatum; Inflammation; Interleukin-5; Anti-IL-5 monoclonal antibody. Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000300009 Registros recuperados: 2 Primeira ... 1 ... Última

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