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| Dalpiaz,P.L.M.; Lamas,A.Z.; Caliman,I.F.; Medeiros,A.R.S.; Abreu,G.R.; Moysés,M.R.; Andrade,T.U.; Alves,M.F.; Carmona,A.K.; Bissoli,N.S.. |
| Sex hormones modulate the action of both cytokines and the renin-angiotensin system. However, the effects of angiotensin I-converting enzyme (ACE) on the proinflammatory and anti-inflammatory cytokine levels in male and female spontaneously hypertensive rats (SHR) are unclear. We determined the relationship between ACE activity, cytokine levels and sex differences in SHR. Female (F) and male (M) SHR were divided into 4 experimental groups each (n = 7): sham + vehicle (SV), sham + enalapril (10 mg/kg body weight by gavage), castrated + vehicle, and castrated + enalapril. Treatment began 21 days after castration and continued for 30 days. Serum cytokine levels (ELISA) and ACE activity (fluorimetry) were measured. Male rats exhibited a higher serum ACE... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: SHR Enalapril Sexual dimorphism Angiotensin I-converting enzyme Cytokines IL-10; IL-6 and TNF-α. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013000200171 |
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| Franquini,J.V.M.; Medeiros,A.R.S.; Andrade,T.U.; Araújo,M.T.M.; Moysés,M.R.; Abreu,G.R.; Vasquez,E.C.; Bissoli,N.S.. |
| Obstructive apnea (OA) can exert significant effects on renal sympathetic nerve activity (RSNA) and hemodynamic parameters. The present study focuses on the modulatory actions of RSNA on OA-induced sodium and water retention. The experiments were performed in renal-denervated rats (D; N = 9), which were compared to sham (S; N = 9) rats. Mean arterial pressure (MAP) and heart rate (HR) were assessed via an intrafemoral catheter. A catheter was inserted into the bladder for urinary measurements. OA episodes were induced via occlusion of the catheter inserted into the trachea. After an equilibration period, OA was induced for 20 s every 2 min and the changes in urine, MAP, HR and RSNA were recorded. Renal denervation did not alter resting MAP (S: 113 ± 4 vs... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Obstructive apnea; Renal nerve; Natriuresis; Diuresis. |
| Ano: 2009 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000200010 |
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