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Effects of metformin treatment on luteal phase progesterone concentration in polycystic ovary syndrome BJMBR
Meenakumari,K.J.; Agarwal,S.; Krishna,A.; Pandey,L.K..
The causes of luteal phase progesterone deficiency in polycystic ovary syndrome (PCOS) are not known. To determine the possible involvement of hyperinsulinemia in luteal phase progesterone deficiency in women with PCOS, we examined the relationship between progesterone, luteinizing hormone (LH) and insulin during the luteal phase and studied the effect of metformin on luteal progesterone levels in PCOS. Patients with PCOS (19 women aged 18-35 years) were treated with metformin (500 mg three times daily) for 4 weeks prior to the test cycle and throughout the study period, and submitted to ovulation induction with clomiphene citrate. Blood samples were collected from control (N = 5, same age range as PCOS women) and PCOS women during the late follicular (one...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Polycystic ovary syndrome; Metformin; Luteal phase defect; Progesterone.
Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004001100007
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